Multiple sclerosis (MS) probably occurs by oxidative, inflammatory and autoimmune mechanisms. This study investigated the influence of statin on the stability of erythrocyte membranes in MS patients. The population was composed of one group with simvastatin therapy (20 mg/day), another group without statin therapy and a healthy control group. The stability of erythrocytes was evaluated by the half-transition points, H(50) and D(50), obtained from the curves of hemolysis induced by hypotonic shock and ethanol action, respectively. Erythrocytes of MS patients were less stable against lysis by both chaotropes. This behavior may be merely a consequence of the lifestyle of MS patients or it may be intrinsically associated with the conjunct of factors responsible for the development of the disease. The use of statin by MS patients was associated with lower levels of LDL and total cholesterol, as expected, and with higher stability of erythrocytes against ethanol compared to the values of untreated MS patients.
A terapêutica convencional da esclerose múltipla (EM) compreende o uso de imunossupressores e imunomoduladores. Como as estatinas têm ações antiinflamatórias e imunomoduladoras, elas poderiam constituir uma terapia alternativa para essa doença. Descrevemos neste trabalho o resultado do uso de rosuvastatina por uma paciente de 34 anos, portadora de EM remitente-recorrente. A paciente iniciou tratamento com interferon-beta 1A, porém, após queixas de efeitos adversos, recusou-se a continuar o tratamento. Em 2005, ela iniciou uso de rosuvastatina. Seu EDSS (Expanded Disability Status Scale) era igual a 6,0. Após 6 meses de tratamento, ela apresentava boa evolução no quadro neurológico, passando a deambular distâncias maiores e a praticar exercícios físicos. Seu EDSS baixou para 4,5. O tratamento com estatina é racionalmente promissor na melhoria da qualidade de vida e, provavelmente, no controle da doença.
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