Influence of the Use of Statin on the Stability of Erythrocyte Membranes in Multiple Sclerosis

Abstract

Multiple sclerosis (MS) probably occurs by oxidative, inflammatory and autoimmune mechanisms. This study investigated the influence of statin on the stability of erythrocyte membranes in MS patients. The population was composed of one group with simvastatin therapy (20 mg/day), another group without statin therapy and a healthy control group. The stability of erythrocytes was evaluated by the half-transition points, H(50) and D(50), obtained from the curves of hemolysis induced by hypotonic shock and ethanol action, respectively. Erythrocytes of MS patients were less stable against lysis by both chaotropes. This behavior may be merely a consequence of the lifestyle of MS patients or it may be intrinsically associated with the conjunct of factors responsible for the development of the disease. The use of statin by MS patients was associated with lower levels of LDL and total cholesterol, as expected, and with higher stability of erythrocytes against ethanol compared to the values of untreated MS patients.

Relationship between serum cholesterol and indices of erythrocytes and platelets in the US population

“…Cholesterol quartiles derived from NHANES [2005][2006] were used to analyze both surveys: 1 ) HDL-C [low ( р 41.83 mg/dl), medium (>41.83-51.38 mg/dl), high (>51. .93 mg/dl), very high(>62.93 mg/dl)]; and 2 ) non-HDL-C [low ( р 114.42 mg/dl), medium (>114.42-140.1 mg/dl), high window of cholesterol content, above which it, along with erythrocyte and platelet lifespan, is compromised ( 4,6,17 ).…”

“…For example, malnutrition are all positively correlated ( 34 ). It has also been proposed that the stability of erythrocytes may be maximal within an optimal range of membrane fl uidity (and thus membrane cholesterol) ( 17 ). Thus, under cholesterolloading conditions that exceed the critical range, erythrocyte membrane stability is impaired, likely accounting for the increased erythrocyte osmotic fragility and spur cell and hemolytic anemias seen in experimental animals fed a high-cholesterol diet ( 10,12 ), and the erythrocyte membrane damage observed in hypercholesterolemic humans ( 9 ).…”

“…Thus, under cholesterolloading conditions that exceed the critical range, erythrocyte membrane stability is impaired, likely accounting for the increased erythrocyte osmotic fragility and spur cell and hemolytic anemias seen in experimental animals fed a high-cholesterol diet ( 10,12 ), and the erythrocyte membrane damage observed in hypercholesterolemic humans ( 9 ). Conversely, LDL-C reduction in hypercholesterolemic multiple sclerosis patients with statin therapy has been shown to increase erythrocyte stability ( 17 ).…”

Red cell distribution width, other hematological parameters and atherogenic index of plasma in patients with clopidogrel and aspirin resistance

“…The stability of erythrocytes may be maximal within an optimal range of membrane fluidity [18]. Increases in erythrocyte membrane cholesterol levels are responsible for the deterioration of cell deformability, which affects the lifespans of circulating erythrocytes, and this results in elevated RDW values [13,17,18].…”

Evaluation of In Vitro Radical Scavenging and Antihemolytic Efficacy of a Polyherbal Combination Prepared from Traditional Blood Purifiers

“…Rupture of RBC membrane releases haemoglobin which can be measured spectrophotometrically (De Freitas et al, 2010). In this work, oxidative damage of erythrocytes was induced by using H 2 O 2 and the protective effect of the PHC against the free radical induced oxidative damage was assessed.…”