Global DNA methylation and hydroxymethylation might be biomarkers for obesity and associated comorbidities. Depending on the obesity treatment (diet or surgery), the DNA methylation patterns behave differently. Baseline SERPINE-1 methylation may be a predictor of weight loss values after bariatric surgery.
Six months after bariatric surgery and significant weight loss, many molecular pathways involved in obesity and metabolic diseases change. These findings are an important tool to identify potential targets for therapeutic intervention and clinical practice of nutritional genomics in obesity.
Our study aimed to associate IL-1β and IL-1RN polymorphisms with AD disease in comparison with elderly control group from São Paulo - Brazil. We genotyped 199 Alzheimer's disease (AD) patients, 165 elderly control and 122 young control samples, concerning VNTR (IL-1RN) and -511C>T and -31T>C (IL-1β) polymorphisms. Our findings revealed that -511C/-31T/2-repetitions VNTR haplotype had a protective effect for AD when compared to EC (p=0.005), whereas -511C/-31C/1-repetition VNTR haplotype was associated as a risk factor for AD (p=0.021). Taken together, we may suggest that there is a relevant role of IL-1 genes cluster in AD pathogenesis in this Brazilian population.
BackgroundSeveral studies have evaluated the oxidant and antioxidant status of thalassemia
patients but most focused mainly on the severe and intermediate states of the
disease. Moreover, the oxidative status has not been evaluated for the different
beta-thalassemia mutations. ObjectiveTo evaluate lipid peroxidation and Trolox equivalent antioxidant capacity in
relation to serum iron and ferritin in beta thalassemia resulting from two
different mutations (CD39 and IVS-I-110) compared to individuals without
beta-thalassemia. MethodsOne hundred and thirty subjects were studied, including 49 who were heterozygous
for beta-thalassemia and 81 controls. Blood samples were subjected to screening
tests for hemoglobin. Allele-specific polymerase chain reaction was used to
confirm mutations for beta-thalassemia, an analysis of thiobarbituric acid
reactive species was used to determine lipid peroxidation, and Trolox equivalent
antioxidant capacity evaluations were performed. The heterozygous beta-thalassemia
group was also evaluated for serum iron and ferritin status. ResultsThiobarbituric acid reactive species (486.24 ± 119.64 ng/mL) and Trolox equivalent
antioxidant capacity values (2.23 ± 0.11 mM/L) were higher in beta-thalassemia
heterozygotes compared to controls (260.86 ± 92.40 ng/mL and 2.12 ± 0.10 mM/L,
respectively; p-value < 0.01). Increased thiobarbituric acid reactive species
values were observed in subjects with the CD39 mutation compared with those with
the IVS-I-110 mutation (529.94 ± 115.60 ng/mL and 453.39 ± 121.10 ng/mL,
respectively; p-value = 0.04). However, average Trolox equivalent antioxidant
capacity values were similar for both mutations (2.20 ± 0.08 mM/L and 2.23 ± 0.12
mM/L, respectively; p-value = 0.39). There was no influence of serum iron and
ferritin levels on thiobarbituric acid reactive species and Trolox equivalent
antioxidant capacity values. ConclusionThis study shows an increase of oxidative stress and antioxidant capacity in
beta-thalassemia heterozygotes, mainly in carriers of the CD39 mutation.
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