The auriculotemporal nerve is one branch of the mandibular portion of the trigeminal nerve, which itself divides into several branches in the temporal and retromandibular regions. The lesser occipital nerve is a cutaneous branch of the cervical plexus and is sometimes implicated in cases of cervicogenic headaches, occipitoparietal headaches, and occipital neuralgia, in general. Here, we present a case of unilateral neural interconnection between the auriculotemporal and lesser occipital nerves thus illustrating the joining of the cervical plexus and trigeminal nerve. A better understanding of the aforementioned nervous anatomy may be valuable for facial reconstructive and nerve transfer procedures, as well as for a variety of other head and neck disorders, e.g., occipital neuralgia.
Circular dichroism and dye leakage assays revealed that the amidated Cterminus maintains better peptide structural stability and ability to disrupt membranes than the carboxylic form. Similarly, 31 P and 2 H solid-state NMR displayed that the C-terminal amidated peptide had a stronger interaction with the phospholipid headgroups and a slight effect on the lipid acyl chains. Cell viability and antibacterial assays showed that the amidated C-terminus induced greater antibacterial and cytotoxic effect while the carboxylic C-terminus promoted mild cytotoxic effect and reduced antibacterial efficacy. Overall, the results showed that the C-terminus of maculatin is critical in modulating the peptide mode of action.
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