Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) Can Be Vertically Transmitted from Infected Mothers to Their Fetuses Leading to Respiratory Symptoms in the Offspring

Desai, S.P.; Agbodji, Ayitevi; Craig, Kellina M.; Pennie, E.; Brown, Rachel; Trinh, Ivy; Rambaran, Saraswatie; Gebara, Marc A; Medearis, S.; Carrión, Freddy G; Dugas, Courtney; Li, Y.; Satou, Ryousuke; Robinson, J.; Norton, Elizabeth B.; Ley, Sylvia H.; Pridjian, Gabriella; Longo, Sherri; Piedimonte, Giovanni

doi:10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1158

A26. Cutting Edge Pediatric Covid-19 Science 2022

DOI: 10.1164/ajrccm-conference.2022.205.1_meetingabstracts.a1158

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Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) Can Be Vertically Transmitted from Infected Mothers to Their Fetuses Leading to Respiratory Symptoms in the Offspring

S.P. Desai

Ayitevi Agbodji

Kellina M. Craig

et al.

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2024

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“…To address these questions, we began a multisite prospective cohort study of 105 dyads, each comprising a pregnant woman delivering a full-term newborn between 2020 and 2022 in greater New Orleans, Louisiana, including clinical outcomes recorded in the perinatal period (e.g., weight, length of hospital stay). Some of the results of these studies have been previously reported in abstract form ( 4 , 5 ).…”

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confidence: 90%

Prenatal Infection by Respiratory Viruses Is Associated with Immunoinflammatory Responses in the Fetus

Trinh,

Desai,

Ley

et al. 2024

Am J Respir Crit Care Med

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Rationale Respiratory viral infections can be transmitted from pregnant women to their offspring, but frequency, mechanisms, and postnatal outcomes remain unclear. Objectives The aims of this prospective cohort study were to compare the frequencies of transplacental transmission of respiratory syncytial virus (RSV) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), analyze the concentrations of inflammatory mediators in maternal and fetal blood, and assess clinical consequences. Methods We recruited pregnant women who developed upper respiratory infections or tested positive for SARS-CoV-2. Maternal and cord blood samples were collected at delivery. Study questionnaires and electronic medical records were used to document demographic and medical information. Measurements and Main Results From October 2020 to June 2022, droplet digital PCR was used to test blood mononuclear cells from 103 mother–baby dyads. Twice more newborns in our sample were vertically infected with RSV compared with SARS-CoV-2 (25.2% [26 of 103] vs. 11.9% [12 of 101]; P = 0.019). Multiplex ELISA measured significantly increased concentrations of several inflammatory cytokines and chemokines in maternal and cord blood from newborns, with evidence of viral exposure in utero compared with control dyads. Prenatal infection was associated with significantly lower birth weight and postnatal weight growth. Conclusions Data suggest a higher frequency of vertical transmission for RSV than SARS-CoV-2. Intrauterine exposure is associated with fetal inflammation driven by soluble inflammatory mediators, with expression profiles dependent on the virus type and affecting the rate of viral transmission. Virus-induced inflammation may have pathological consequences already in the first days of life, as shown by its effects on birth weight and postnatal weight growth.

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confidence: 90%

Prenatal Infection by Respiratory Viruses Is Associated with Immunoinflammatory Responses in the Fetus

Trinh,

Desai,

Ley

et al. 2024

Am J Respir Crit Care Med

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Respiratory Syncytial Virus (RSV) and Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-Cov-2) Can Be Vertically Transmitted from Infected Mothers to Their Fetuses Leading to Respiratory Symptoms in the Offspring

Cited by 1 publication

References 0 publications

Prenatal Infection by Respiratory Viruses Is Associated with Immunoinflammatory Responses in the Fetus

Prenatal Infection by Respiratory Viruses Is Associated with Immunoinflammatory Responses in the Fetus

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