The use of oil-in-water emulsions for controlled lipid release is of interest to the pharmaceutical industry in the development of poorly water soluble drugs and also has gained major interest in the treatment of obesity. In this study, we focus on the relevant in vitro parameters reflecting gastric and intestinal digestion steps to reach a reliable in vitro-in vivo correlation for lipid delivery systems. We found that (i) gastric lipolysis determines early lipid release and sensing. This was mainly influenced by the emulsion stabilization mechanism. (ii) Gastric mucin influences the structure of charge-stabilized emulsion systems in the stomach, leading to destabilization or gel formation, which is supported by in vivo magnetic resonance imaging in healthy volunteers. (iii) The precursor structures of these emulsions modulate intestinal lipolysis kinetics in vitro, which is reflected in plasma triglyceride and cholecystokinin concentrations in vivo.
Abstract. Short range radar (SRR) for cars has been proposed to operate over 5 GHz of bandwidth at the 24 GHz ISM band. To estimate the level of interference from these devices on radio telescopes, the near-field antenna pattern has to be known. We report on new measurements with the Effelsberg 100 m radio telescope. These measurements were performed with a transmitter set up at a distance of 1.7 km from the telescope. The strength of the signal picked up by the telescope sidelobes shows that the proposed SRR would interfere with sensitive radio astronomical observations.
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