Ibuprofen as a non-steroidal anti-inflammatory drug (NSAID) show a low and variable oral bioavailability in water solution due to low aqueous solubility and slow dissolution rate. Reducing ibuprofen particles size is an effective and widely used approach to speed up dissolution by enlarging the effective surface area. The ibuprofen nanoparticles are prepared by solvent/antisolvent method. The prepared nanodrug show the accelerate dissolution rate in water solvent. In comparison with raw drug, the chemical structure of nanosized ibuprofen show not change but the crystallinity is reduced to 300-400 nm. The decreasing of particles size ibuprofen is also due to an increase 2.33 times of dissolution in purified water in first 30 min.
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