Preparation and Characterization of Ibuprofen Nanoparticles by using Solvent/ Antisolvent Precipitation

Abstract

Ibuprofen as a non-steroidal anti-inflammatory drug (NSAID) show a low and variable oral bioavailability in water solution due to low aqueous solubility and slow dissolution rate. Reducing ibuprofen particles size is an effective and widely used approach to speed up dissolution by enlarging the effective surface area. The ibuprofen nanoparticles are prepared by solvent/antisolvent method. The prepared nanodrug show the accelerate dissolution rate in water solvent. In comparison with raw drug, the chemical structure of nanosized ibuprofen show not change but the crystallinity is reduced to 300-400 nm. The decreasing of particles size ibuprofen is also due to an increase 2.33 times of dissolution in purified water in first 30 min.

Dual Cross-Linked Carboxymethyl Sago Pulp-Gelatine Complex Coacervates for Sustained Drug Delivery

“…Micronization of ibuprofen native particles was performed using a modified version of the solvent/anti-solvent precipitation method reported previously [18]. Native ibuprofen was dissolved in isopropanol until saturation.…”

Antisolvent Crystallization of Poorly Water Soluble Drugs

“…These classes have the limited bioavailability of drugs due to their low solubility and dissolution rate [1]. The bioavailability is defined as the percentage of the quantity of the drug absorbed compared to its initial quantity of dosage, which can be improved by a decrease in their particle size [2]. The dissolution rate of the active pharmaceutical ingredient (API) is proportional to the available surface area for dissolution as described by the Noyes-Whitney equation and, in addition, by an increasing the solubility of nanosized API is also expected to enhance the dissolution rate as described by the Ostwald-Freundlich equation [3].…”

Integrating Drug- and Formulation-Related Properties With Gastrointestinal Tract Variability Using a Product-Specific Particle Size Approach: Case Example Ibuprofen

“…13 Having fixed the aqueous solubility parameters, a P-PSD for Nurofen® 200 mg was estimated through modeling of the reported in vitro dissolution profile in phosphate buffer 50 mM at pH 6.7 (30-311 mm; Table 1). The resulting P-PSD is wider than the distribution of raw ibuprofen particle size, for example, reported D [v,0.1] and D [v,0.9] ranging from 25 to 90 mm and 195 to 212 mm, respectively, [22][23][24] seeming to better capture the fusion of some particles during compaction and the attendant decrease in effective surface area of the drug that is in contact with gastrointestinal fluids after disintegration as reported by Le et al 22 The predictive capacity of the resulting simultaneous diffusion and chemical reaction model was verified against an experimental data set obtained in a lower buffer capacity medium, namely phosphate buffer 5 mM, 14 which had not been used to fit the model. Comparison between predicted and observed dissolution profiles resulted in a R 2 !…”