Most of the common redox mediators such as organic dyes and cyanide ligand-associated metal complex systems that have been used for various electrochemical applications are hazardous nature. Sesamol, a vital nutrient that exists in natural products like sesame seeds and oil, shows several therapeutic benefits including anticancer, antidiabetic, cardiovascular protective properties, etc. Herein, we introduce a new electrochemical redox platform based on a sesamol derivative, sesamol-quinone (Ses-Qn; oxidized sesamol), prepared by the in situ electrochemical oxidation method on a carbon nanoblack chemically modified glassy carbon electrode surface (GCE/CB@Ses-Qn) in pH 7 phosphate buffer solution, for nontoxic and sustainable electrochemical, electroanalytical, and bioelectroanalytical applications. The new Ses-Qn-modified electrode showed a well-defined redox peak at Eo = 0.1 V vs Ag/AgCl without any surface-fouling behavior. Following three representative applications were demonstrated with this new redox system: (i) simple and quick estimation of sesamol content in the natural herbal products by electrochemical oxidation on GCE/CB followed by analyzing the oxidation current signal. (ii) Utilization of the GCE/CB@Ses-Qn as a transducer, bioelectrocatalytic reduction, and sensing of H2O2 after absorbing the horseradish peroxidase (HRP)-based enzymatic system on the underlying surface. The biosensor showed a highly selective H2O2 signal with current sensitivity and detection limit values 0.1303 μA μM–1 and 990 nM, respectively, with tolerable interference from the common biochemicals like dissolved oxygen, cysteine, ascorbic acid, glucose, xanthine, hypoxanthine, uric acid, and hydrazine. (iii) Electrochemical immunosensing of white spot syndrome virus by sequentially modifying primary antibody, antigen, secondary antibody (HRP-linked), and bovine serum albumin on the redox electrode, followed by selective bioelectrochemical detection of H2O2.

No abstract

No abstract

Isomers of dihydroxy benzene (DHB) such as 1,2-DHB, 1,3-DHB and 1,2,3-trihydroxy benzene (1,2,3-THB) are the functional electro-active constituents of tea polyphenols.

No abstract

No abstract

Herein, we report a simple electroanalytical detection method based on ultra-low cost pencil graphite as an elegant sensor for simultaneous and separation-free detection of Hx, X and UA.

Recently, nanotechnology applications have increased tremendously in consumer products. However, it has been observed that these nanoparticles can cause a potential risk to the environment as well as human health. In the present manuscript, we have analyzed acute and sub-chronic toxicity of engineered silver nanoparticles (AgNPs) by assessing the impact on Wistar rats. AgNPs were synthesized by a novel approach-thermal co-reduction-with spherical shape and a uniform size distribution of 60 nm. The estimated LD 50 value was observed to be more than 2000 mg/kg bw in acute toxicity studies. Subchronic toxicity indicated impairment of liver and kidney enzymes and various hematological and biochemical parameters. Tissue distribution studies indicated the target organ for accumulation is liver after treatment with AgNP. Particle deposition and congestion was observed in major organs-though, and heart and pancreatic tissues were not affected even by the higher doses. On the basis of the observations of this study, it is concluded that up to 40 mg/kgbw is a safer dose of AgNPs (60 nm, engineered by thermal co-reduction approach) and further research will be required to validate the long-term accumulation in body. In addition, it can also be considered by policymakers for the safer use of AgNPs.