Toxicity and regulations of food nanomaterials

Ranjan, Shivendu; Dasgupta, Nandita; Singh, Satnam; Gandhi, Mansi

doi:10.1007/s10311-018-00851-z

Cited by 37 publications

(13 citation statements)

References 107 publications

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“…The preparation of CuO nanoparticles in Milli-Q water rather than ethylene glycol or mixture of ethylene glycol/water may be conceptualized as one of the best methods of synthesis of the NPs (Kamalgharibi et al 2016 ). It can be noted that the toxicological impact of nanomaterials varies from size and mode of fabrication, both in vitro and in vivo (Ranjan et al 2020 a; Ranjan et al 2020 b; Kumar et al 2020 ; Dasgupta et al 2019 ; Ranjan et al 2019 ; Dasgupta et al 2018 ; Ranjan et al 2018 ; Aditi et al 2018 ; Ranjan and Chidambaram 2016 a; Dasgupta and Chidambaram 2016 ; Ranjan et al 2016 a; Dasgupta et al 2016 a; Ranjan et al 2016 b; Dasgupta et al 2016 b; Saxena et al 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Biosynthesis, characterization of PLGA coated folate-mediated multiple drug loaded copper oxide (CuO) nanoparticles and it’s cytotoxicity on nasopharyngeal cancer cell lines

Guo

Zhao

et al. 2020

AMB Expr

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Cytotoxicity of CuO nanoparticles (NPs) are an impediment in utilizing them as an effective nanocarriers of chemotherapeutic drugs for targeted drug delivery in nasopharyngeal cancer. In our current study, we have designed a two-step synthesis and coating of CuO NPs with different concentrations of PLGA (polylactide-co-glycolide) to reduce the cytotoxicity. This was further conjugated with folic acid to enhance targeting to specific tissue. The multiple drugs loaded in the NPs were two potent anticancer drugs doxorubicin and docetaxel. A complete characterization studies including micrographic analysis, zeta potential measurements, polydispersity index, Fourier transform infrared spectroscopy (FTIR), encapsulation and loading efficiencies, stability and in vitro release studies were done. Cytoxicity studies were done with MTT 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay, acridine orange/ethidium bromide and DAPI (4, 6-diamidino-2-phenylindole, dihydrochloride) staining procedures. Impediametric studies were also carried out to reinforce the reduction in cytotoxicity. Finally the cellular uptake of the NPs was seen. It was evident from the results that the multiple drugs loaded CuO NPs formed with PLGA coating were uniform, non-agglomerated in size ranging from 180 to 195 nm. The FTIR revealed no major changes in drug peaks. Encapsulation and loading efficiencies showed sufficient amount of drug being loaded into the NPs. The drug loaded NPs showed no change in size or zeta potential even after a period of 30 days. The cytotoxicity studies revealed significant reduction in toxicity after coating the surface treated with PLGA as evident from the microscopic analysis of cells. Hence the current study may be prioritized and further in vivo/in vitro studies may be carried out.

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Section: Discussionmentioning

confidence: 99%

Biosynthesis, characterization of PLGA coated folate-mediated multiple drug loaded copper oxide (CuO) nanoparticles and it’s cytotoxicity on nasopharyngeal cancer cell lines

Guo

Zhao

et al. 2020

AMB Expr

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“…Reducing the size of the droplets in nanoemulsions usually increases their stability to gravitational separation and aggregation, but it may reduce their chemical stability because of the large contact area between the oil and water phases (Erdmann et al., 2017; Salminen et al., 2013). For instance, an increase in lipid oxidation is usually undesirable because it reduces the sensory attributes of foods and may lead to the generation of potentially toxic reaction products (Ranjan, Dasgupta et al., 2019).…”

Section: Limitationsmentioning

confidence: 99%

Application of nanoemulsion‐based approaches for improving the quality and safety of muscle foods: A comprehensive review

Das

Nanda

Bandyopadhyay

et al. 2020

Comp Rev Food Sci Food Safe

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Recently, there has been growing interest in implementing innovative nanoscience‐based technologies to improve the health, safety, and quality of food products. A major thrust in this area has been to use nanoemulsions because they can easily be formulated with existing food ingredients and technologies. In particular, oil‐in‐water nanoemulsions, which consist of small oil droplets (<200 nm) dispersed in water, are being utilized as delivery systems for various hydrophobic substances in foods, including nutrients, nutraceuticals, antioxidants, antimicrobials, colors, and flavors. In this article, we focus on the application of nanoemulsion‐based delivery systems for improving the quality, safety, nutritional profile, and sensory attributes of muscle foods, such as meat and fish. The article also critically reviews the formulation and fabrication of food‐grade nanoemulsions, their potential benefits and limitations in muscle food systems.

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“…Since a variety of ENMs are increasingly utilized in different food items such as toothpastes, foods, and food packaging, [84] substantial concerns have been raised on the hazard effects of these materials by oral exposure. ENM behavior at nanobio interfaces of gastrointestinal (GI) tract may become an important research area in future.…”

Section: Ingestionmentioning

confidence: 99%

Molecular Mechanisms, Characterization Methods, and Utilities of Nanoparticle Biotransformation in Nanosafety Assessments

Cai

Liu

Jiang

et al. 2020

Small

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It is a big challenge to reveal the intrinsic cause of a nanotoxic effect due to diverse branches of signaling pathways induced by engineered nanomaterials (ENMs). Biotransformation of toxic ENMs involving biochemical reactions between nanoparticles (NPs) and biological systems has recently attracted substantial attention as it is regarded as the upstream signal in nanotoxicology pathways, the molecular initiating event (MIE). Considering that different exposure routes of ENMs may lead to different interfaces for the arising of biotransformation, this work summarizes the nano–bio interfaces and dose calculation in inhalation, dermal, ingestion, and injection exposures to humans. Then, five types of biotransformation are shown, including aggregation and agglomeration, corona formation, decomposition, recrystallization, and redox reactions. Besides, the characterization methods for investigation of biotransformation as well as the safe design of ENMs to improve the sustainable development of nanotechnology are also discussed. Finally, future perspectives on the implications of biotransformation in clinical translation of nanomedicine and commercialization of nanoproducts are provided.

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Toxicity and regulations of food nanomaterials

Cited by 37 publications

References 107 publications

Biosynthesis, characterization of PLGA coated folate-mediated multiple drug loaded copper oxide (CuO) nanoparticles and it’s cytotoxicity on nasopharyngeal cancer cell lines

Biosynthesis, characterization of PLGA coated folate-mediated multiple drug loaded copper oxide (CuO) nanoparticles and it’s cytotoxicity on nasopharyngeal cancer cell lines

Application of nanoemulsion‐based approaches for improving the quality and safety of muscle foods: A comprehensive review

Molecular Mechanisms, Characterization Methods, and Utilities of Nanoparticle Biotransformation in Nanosafety Assessments

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