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Objectives:The aim of this study has been to investigate the possible antihyperlipidemic effect of Salacia chinensis root extract in triton (400mg/kg b.w.)-induced and atherogenic diet-induced hyperlipidemic rats.Materials and Methods:Petroleum ether (60-80°C), chloroform, ethanol and aqueous extracts of Salacia chinensis roots were evaluated for antihyperlipidemic activity in triton- and atherogenic diet-induced hyperlipidemic rats. A comparison was also made between the action of Salacia chinensis root extract and a known antihyperlipidemic drug simvastatin (10 mg/kg body wt.). The results of the study were expressed as mean± S.E. and data was analyzed by using one way analysis of variance test (ANOVA) followed by Dunnett's t-test for multiple comparisons. Values with P < 0.05 were considered as significant.Results:Oral administration of 500 mg/kg body wt. of the chloroform extract and alcoholic extract of Salacia chinensis root exhibited a significant reduction (P<0.01) in serum lipid parameters like total cholesterol, triglycerides, low density lipoprotein (LDL), very low density lipopreotein (VLDL) and increase in high density lipoprotein (HDL) in hyperlipidemic rats of both models as compared to hyperlipidemic control statistically. These extracts were found to possess better antihyperlipidemic potential as compared to pet ether and aqueous extract.Conclusions:Our results demonstrated that chloroform and alcoholic extract of Salacia chinensis roots possessed significant antihyperlipidemic activity and hence it could be a potential herbal medicine as adjuvant with existing therapy for the treatment of hyperlipidemia.

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Sodium alginate (SA) floating beads containing cefpodoxime proxetil, a third-generation cephalosporin antibiotic, were prepared by precipitation method using calcium carbonate as gas generating agent. Hydroxypropyl methylcellulose (HPMC) was used in all the four formulations in different proportions (F1, F2, F3, and F4) as swelling agent to control the release of the drug. Gas generating agent forms pores on the surface of the beads because of the rapid escape of CO 2 during the curing process in precipitating media. Scanning electron microscopy confirmed their porous and grossly spherical structure, and the size of the beads were in the range of 700-1000 lm. The size of the beads increases with the increase in the concentration of gas-forming agent and decreases with the increase in the concentration SA. The drug entrapment efficiency was found to be in the range of 85.3-91.1%. F2shows least entrapment, whereas F3 shows maximum entrapment. The percentage porosity was 82.1-89.1%, and the mean pore diameter was 0.41-0.52 lm. The porosity depends on the concentration of gas-forming agent. The mechanical strength of the beads was 591-1073 g. All the formulations showed good floating time. The in vitro release was performed in glycine dissolution media according to USP for about 12 h. The cumulative % drug release was found to be 67.5-87.3%. The in vitro dissolution study reveals that the concentration of the gas generating agent and SA affects the release rate.

Dental implant is a pharmaceutical device in the form of strip with very small loading and size of 0.25 sq cm. For site-specific one-time continuous delivery of ornidazole an antimicrobial compound with excellent activity against anaerobic microorganism in the treatment of periodontal disease was prepared by solvent casting technique using ethyl cellulose, hydroxypropylcellulose, hydroxypropylmethylcellulose K4M and Eudragit RL-100 with dibutylphthalate as plasticizer. The physicochemical parameters like thickness, weight variation, content uniformity and release characteristics were evaluated The drug release was initially high on day one to achieve immediate therapeutic level of drug in pocket, followed by marked fall in release by day two, and progressive moderate release profile to maintain therapeutic level following anomalous transport mechanism. Formulation V6 released 97.07% of drug at the end of 120 h and was considered as best formulation. In vitro antibacterial activity was carried out on Streptococcus mutans. Preparation of dental implants: Method used for the preparation of dental implants was solvent casting technique 3 using chloroform and dichloromethane (1:1) mixture. A total of six formulations

Alcoholic extract of Bermuda grass (Cynodon dactylon) was evaluated for preliminary identification of phytoconstituents and screened at 200, 400, and 600 mg/kg b.w given orally for pylorus ligated and indomethacin induced gastric ulcer models in albino rats. Results showed the presence of flavonoids and proteins. Alcoholic extracts at 400 mg/kg and 600 mg/kg showed significant (p<0.001) antiulcer activity, comparable to the standard drug ranitidine, which may be due to the presence of flavonoids.

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