No abstract

The herbal medicines are selecting over modern medicine due to their efficacy, safety, and lesser side effects. Cassia auriculata extremely used in Ayurvedic medicine. C. auriculata is commonly known as tanner's cassia, and it belongs to the family Caesalpiniaceae. It is reported to contain many phytoconstituents such as alkaloids, terpenoids, phenols and tannins, sugar saponins, flavonoids, quinines, steroids, and proteins. The ethnobotanical survey revealed that the C. auriculata was used for the treatment of diabetes, joint pain and inflammation, muscle pain, illness, cold, venereal disease, hair cleanser, reduce body heat, abdominal pain, vomiting, diarrhoea, and toothache. C. auriculata have many pharmacological properties, such as anti-diabetic, anti-oxidant, hepatoprotective, anticancer, anti-inflammatory, anti-hyperlipidemic activities, and many more. The present review focused on its botanical characters, phytochemical constituents, ethnobotanical uses, and pharmacological properties of C. auriculata.

Objective: The present study aims to investigate the protective effect of methanol fraction of Morus alba (MEMA) leaves against hydrogen peroxide (H2O2)-induced U87MG cell toxicity and aluminum fluoride (ALF)-induced rat toxicity. Methods: The study was divided into in vitro and in vivo sections. U87MG cell lines were pre-treated with different fractions of MEMA for 20 h and further tested against 1000 ϻM of H2O2. The best fraction from in vitro studies was used to study the protective effects against ALF-induced neurotoxicity. Rats were divided i nto five different groups, and MEMA (200 and 400 mg/kg p.o) was administered for 14 days to the animals with α-tocopherol as the standard drug treatment. Behavioral studies were assessed using Barnes maze. The major biochemical measurements included catalase, superoxide dismutase and glutathione reductase, lipid peroxidation (LPO), and acetylcholinesterase (AchE) levels. Results: In vitro studies indicated MEMA as a potential candidate followed by AQMA and ethyl acetate. The MEMA fraction was able to ameliorate ALF-induced neurotoxicity in the behavioral assessment. The higher antioxidant content in the fraction decreased the LPO levels from 250±4.07 to 115±3.22 as well as elevated the levels of most of the endogenous antioxidant enzyme levels. AchE levels were also decreased to 33.89±0.71 from 38.94±0.64. Conclusion: Although the results obtained indicate that MEMA could significantly suppress oxidative stress-induced central neuronal damage both in vitro and in vivo, further mechanistic studies are required to delineate its neuroprotective pathway.

Cancer is the third leading cause of death worldwide. The current cancer treatments such as chemotherapy and radiotherapy resulting in the development of unintended adverse effects that reduce the quality of life and economic burden in oncology patients. Nutraceuticals along with food value have natural bioactive components that have reassuring therapeutic properties in several diseases. Herbs of significant interest have been proven to prevent and treat various types of cancer and also reduce the side effects of chemotherapy and radiotherapy. The efficacy of nutraceuticals and herbs such as chemopreventive and chemotherapy is highlighted. We conclude that further studies are required to countersign the targeted approaches and efficacy of herbs and nutraceuticals in cancer patients as adjuvant therapy.