Recent advance of herbal medicines in cancer- a molecular approach

Jatrophone: a cytotoxic macrocylic diterpene targeting PI3K/AKT/NF-κB pathway, inducing apoptosis and autophagy in resistant breast cancer cells

“…Accumulating data indicates the intricate association between apoptosis and autophagy in response to various anticancer treatments [ 45 – 47 ]. The evidence suggests that the induction of autophagy/apoptosis, either dependently or independently is a new strategy to overcome drug resistance [ 48 ] and as a druggable anticancer therapeutic target of naturally derived phytochemicals [ 49 ]. Here, jatrophone added to apoptosis-recruitment, induced autophagic cell death in resistant breast cancer cells This study indicates the potential of jatrophone in preventing the progression of resistant breast cancer cells by triggering apoptotic or autophagic cell death, the main goals of tumor chemoprevention [ 45 , 47 , 50 ].…”

A common molecular and cellular pathway in developing Alzheimer and cancer

“… EGFR Inhibitor Effects in Cancer Effects in AD Ref Gefitinib First-generation EGFR TKI for the treatment of lung cancer Reduces the memory loss caused by Aβ in Drosophila AD model and APP/PS1 transgenic mice [ [168] , [169] , [170] ] Inhibits the levels of extracellular Aβ40/42 and lowers the activity of β-secretase (BACE-1) in N2a cells that overexpress APP. Enhances the cognitive abilities of Swiss albino mice Erlotinib Inhibits the development of tumours in human endometrial cancer cell lines HEC-1A Greatly improves the Drosophila performance index in cases of Aβ42-induced memory loss [ 171 , 172 ] Afatinib Second-generation EGFR-TKI with anti-inflammatory characteristics stops the activation of astrocytes [ 173 , 174 ] Inhibits the hepatocellular carcinoma (HCC) cells' ability to proliferate, migrate, and invade prevents the development of brain tumours in glioblastoma cells by controlling EGFRvIII-cMet signaling in combination with temozolomide Lowers the activation of caspase-1 and proinflammatory cytokine levels in CTXTNA2 cells Varlitinib FDA-approved inhibitor of EGFR/HER2 Reduces tau pathology and LPS-mediated neuroinflammatory responses in tau-overexpressing PS19 and wild-type mice [ 175 , 176 , [214] , [215] , [216] , 219 ] Inhibits the development of mammospheres, cell migration, and invasion in triple-negative breast cancer (TNBC) cells Lapatinib Dual TKI that targets HER2 and EGFR Lowers Aβ1-42 and p-tau levels and improves cognitive impairment in rats with d-galactose/ovariectomized ovaries …”

LC-HRMS analysis of corn mint Mentha arvensis L. for anticancer activity against triple-negative breast cancer targeting inflammatory and apoptosis signaling pathways

“…In the modern world, the emergence of medicinal plants for the treatment of cancer is incredible owing to their significant biomedical applications with no side effects. 4 Especially, certain classes of medicinal plant-based compounds, such as dietary fiber, phenolic acids, flavonoids, terpenoids, alkaloids, and saponins, are broadly accepted to combat common diseases, such as cancer, inflammation, and diabetes. 5,6 Among them, M. arvensis (the plant name was verified at ; accessed on 23 March 2012) is traditional medicine and the recent reports stated that M. arvensis has been traditionally used in patients with hypertension and ischemic heart disease.…”