Clinico-hematological Analysis of Pancytopenia in Adults-A Two Year Prospective Study EDTA anticoagulated blood (2ml) was collected, processed through automated 5part differential cell analyzer and hematological parameters were obtained. Peripheral blood smear was stained with Field's and Leishman stain and examined for RBC, WBC and platelet morphology along with hemoparasites. Anemias were classified morphologically as normocytic normochromic, microcytic hypochromic, macrocytic & dimorphic anemia. Informed consent was taken before performing bone marrow aspiration in cases where it was required. Special tests: Rapid malarial antigen test, dengue card test, leptospirosis card test, tests for HIV, Hepatitis viruses, serum vitamin B12, serum iron studies, liver and renal function tests and tests for tuberculosis, USG abdomen, CT and MRI scans, PET scans, etc. were also performed.
Background: Anemia in pregnancy is a major public health problem worldwide and is the most common hematological disorder during pregnancy. According to WHO, 35 to 75% of pregnant women in developing countries are anemic. Material and Methods: A prospective study was conducted among 100 pregnant women in their first trimester who attended antenatal clinic in a tertiary care hospital. Socio-demographic information were collected along with the blood samples. Hemoglobin concentration, blood indices, PCV, RDW, WBC and RBC counts were determined by a hematological auto-analyzer. Anemia was graded according to WHO criteria and morphological typing of anemia was done on the basis of peripheral blood smear examination. Result: A high prevalence (64%) of anemia was observed among 100 pregnant women of which majority had mild anemia (50%), moderate anemia (48.4%) and severe anemia (1.6%) commonly seen in younger age group (20-24 years). Factors such as age at marriage, age at first childbirth, illiteracy, gravida, working status, residence and socioeconomic status were found to be significantly. According to blood indices and peripheral blood smear analysis microcytic hypochromic anemia (59.4%) was the commonest morphological type of anemia followed by dimorphic anemia (23.4%). Iron deficiency anemia was found to be the commonest cause of anemia in pregnancy. Conclusion: The present study concluded that health education, good nutrition, thorough clinical and hematological examination with iron and folic acid supplements during antenatal period should be implemented to reduce the prevalence of anemia, thus decreasing maternal and fetal morbidity and mortality during pregnancy.
Two rare cases of Kyrle's disease in diabetic patients who presented with papules on legs, back and abdomen, are reported. Pathology of this disease and management are described in detail. Importance of treating the underlying condition associated with this disease is highlighted.
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