Clinico-hematological analysis of pancytopenia in adults – A two year prospective study

Abstract

Clinico-hematological Analysis of Pancytopenia in Adults-A Two Year Prospective Study EDTA anticoagulated blood (2ml) was collected, processed through automated 5part differential cell analyzer and hematological parameters were obtained. Peripheral blood smear was stained with Field's and Leishman stain and examined for RBC, WBC and platelet morphology along with hemoparasites. Anemias were classified morphologically as normocytic normochromic, microcytic hypochromic, macrocytic & dimorphic anemia. Informed consent was taken before performing bone marrow aspiration in cases where it was required. Special tests: Rapid malarial antigen test, dengue card test, leptospirosis card test, tests for HIV, Hepatitis viruses, serum vitamin B12, serum iron studies, liver and renal function tests and tests for tuberculosis, USG abdomen, CT and MRI scans, PET scans, etc. were also performed.

Clinico-Hematological Study of Pancytopenia in Adults at a Tertiary Care Center

“…[6] Patel et al observed that the age of the patients ranged from 15-85 years with male preponderance. [7] Momin et al noted that the age of patients ranged from 2 to 85 years with a mean age of 43 years.…”

“…[6] Patel et al observed that the most common clinical features were weakness (80%), fever (72.1%), pallor (100%) and hepatomegaly (62.8%). [7] Momin et al noted that fever and generalized weakness were common clinical presentations. The commonest physical finding was pallor and splenomegaly on systemic examination.…”

“…[6] Normocytic normochromic was the predominant blood picture in the study done by Patel et al who found that common causes of pancytopenia were malaria (50%), megaloblastic anemia (18.6%) and dengue (18.1%) followed by hypersplenism (7.1%) & iron deficiency anemia(2.7%). [7] Momin et al found that the commonest peripheral smear was dimorphic picture & commonest bone marrow finding was hypercellular marrow with megaloblastic erythroid hyperplasia. The commonest cause for pancytopenia was Megaloblastic anemia (34%) followed by Hematolymphoid malignancy (26.6%).…”