This paper discusses the synthesis and application of graphene oxide (GO)/1-butyl-3-methylimidazolium tetrafluoroborate [BMIM][BF4] nanocomposite. The nanocomposite, GO/[BMIM][BF4],was characterized using X-ray diffraction, X-ray photoelectron spectroscopy, energy dispersive X-ray analysis, field-emission scanning electron microscopy, transmission electron microscopy, Fourier transform infrared spectroscopy, and Raman techniques. The dispersion of [BMIM][BF4] ionic liquid (IL) in the graphene oxide nanochannels provided remarkable interfacial properties to the glassy carbon electrode (GCE) surface. The GO/[BMIM][BF4]modified GCE sensor enhanced the anodic peak current intensity of Embramine (EMB), which was found to be proportional to the drug concentration within the range of 4.9 to 24.7 ng/L, with a detection limit of 1.5 ng/L and the quantification limit of 4.6 ng/L. The redox behavior at varying scan rates revealed that the electro-oxidation process of EMB at GO/IL/GCE was an irreversible diffusion-controlled process. The applicability of the proposed method was further studied for the successful quantification of EMB in the pharmaceutical formulation and human blood plasma.
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