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Summary:We investigated the influence of the adenosine antagonist theophylline on the degree of hippocampal cell damage in the Mongolian gerbil following brief periods of forebrain ischemia. Male gerbils were randomly divided into nine groups. Te n minutes before surgery, four groups, which were later subjected to I, 2, 3, or 5 min of bilateral carotid occlusion under halothane anesthesia, received theophylline (30 mg/kg, p.o.). Four groups served as nontreated ischemic controls; the ninth group was used to measure theophylline serum concentration. Neurological symptoms were classified by using a behav ioral score. Fourteen days after ischemia, the brains were removed, and the hippocampus was histologically exam ined "blind" for the degree of cell damage in the CAl sector, which was expressed as a semiquantitative histo-

Life-long HRA-induced ACE inhibition protects against hypertension-induced renal damages in SHR-SP. This is associated with a doubling of the lifespan in these animals.

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