A simple, rapid, efficient and environmentally benign procedure for the synthesis of chalcones has been achieved by grinding aryl aldehydes and acetophenones with anhydrous barium hydroxide (C-200) in the absence of any solvent. The use of organic solvent for extraction of compound is also avoided. This present method is highly useful for the synthesis of 2?-hydroxy chalcones, required intermediates for the synthesis of flavanoids.
Sodium selenite in dimethylsulfoxide is a highly efficient reagent for dehydrogenation reactions and can be used under both thermal as well as microwave irradiation conditions. Using this reagent benzoins have been dehydrogenated to benzils, flavanones to flavones and 2'-hydroxy chalcones have been converted into flavones by cyclodehydrogenation.
Reaction of 2-hydroxyacetophenones with aromatic acid anhydrides in the presence of anhydrous barium hydroxide in dimethyl sulfoxide using microwave irradiation gives 1-(2-hydroxyphenyl)-3-phenylpropane-1,3-diones directly in a single pot reaction in high yields.
Polyphenylalkane derivatives Q 0720One-Pot Synthesis of 1-(2-Hydroxyphenyl)-3-phenylpropane-1,3-diones by Modified Baker-Venkataraman Transformation Using Microwave Irradiation. -The same reactions under thermal conditions take about 60 minutes with yields of 60-75%. -(LAMBA, M. S.; KUMAR, S.; MAKRANDI*, J. K.; J. Chem. Res. 2006, 2, 133-134; Dep. Chem., Maharshi Dayanand Univ., Rohtak 124 001, India; Eng.) -K. Woydowski 29-080
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