An efficient green procedure for the synthesis of chalcones using C-200 as solid support under grinding conditions

Abstract

A simple, rapid, efficient and environmentally benign procedure for the synthesis of chalcones has been achieved by grinding aryl aldehydes and acetophenones with anhydrous barium hydroxide (C-200) in the absence of any solvent. The use of organic solvent for extraction of compound is also avoided. This present method is highly useful for the synthesis of 2?-hydroxy chalcones, required intermediates for the synthesis of flavanoids.

An improved one-pot and eco-friendly synthesis of aurones under solvent-free conditions

“…Barium hydroxide is a very good solid base catalyst because of its crystalline texture properties (26) and its use has been reported in various organic transformations (21,24). Here in this reaction, when we used hydrated barium hydroxide or other strong bases like NaOH and KOH in place of activated barium hydroxide under these conditions, results were not as good as with activated barium hydroxide.…”

Alkylation-Elimination Reaction in Quaternary Ammonium Salts

“…The impossibility of formation of ylides excludes the course of this reaction. These details are on the mechanism on the validity of our assumption about the mechanism of the occurrence of the process found in the twophase liquid-liquid system [4].…”

Synthesis, Characterization and Biological Evaluation of New 3,5-Disubstituted-Pyrazoline Derivatives as Potential Anti-Mycobacterium tuberculosis H37Ra Compounds

“…The solution was kept in an ice bath until a solid was obtained, and the chalcone compounds were filtered, washed with cold water, dried and recrystallized from ethanol. The results were compared with the literature [ 28 , 29 , 30 , 31 ].…”