Synthesis and Biological Evaluation of 3-(Trimethoxyphenyl)-2(3H)-thiazole Thiones as CombretastatinAnalogues. -A series of thiazole thione derivatives of type (III) and (VI) are prepared and among them, it is shown that (IIIb) exhibits the highest activity against human cancer cell lines T47D, MCF-7 and MDA-MB-231. The cytotoxicity of (IIIc) is selective for the tested cancer cell lines and has no significant toxicity towards non-tumoral cell line (IIIc) depolymerizes tubulin, inhibits cell proliferation and induces apoptosis in cancer cells. -(BANIMUSTAFA, M.; KHEIROLLAHI, A.; SAFAVI, M.; KABUDANIAN ARDESTANI, S.; ARYAPOUR, H.; FOROUMADI, A.; EMAMI*, S.; Eur. J. Med. Chem. 70 (2013) 692-702, http://dx.
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