Synthesis and biological evaluation of 3-(trimethoxyphenyl)-2(3H)-thiazole thiones as combretastatin analogs

Synthesis and anticancer activity of N-substituted 2-arylquinazolinones bearing trans-stilbene scaffold

“…The cytotoxic activities of compounds 7a-o were evaluated by using MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) colorimetric assay as reported method [34,35]. The absorbance was read at 492 nm with an ELISA plate reader (Biotek Instruments, Winooski, Vt.).…”

“…The acridine orange/ethidium bromide test was used to detect apoptosis induced by selected compounds 7d and 7h according to the previously described method [35,36].…”

Structural diversity in dinuclear copper(I) halide complexes of 2,4-dithiouracil: Synthesis, crystal structures, induction of DNA damage and oxidative stress mediated by ROS

“…Thus research interest into their coordination chemistry has been increasingly moved over the years towards potential biological/ medicinal applications, and several imidazole-, thiazole-, thiadiazole-, oxazole-and uracil-based thioamide derivatives and/or their transition metal complexes have been tested towards pharmacological activities, such as antiviral [19], antibacterial [8,20], antiarthritic [21] or antifungal [22]. Moreover, in vitro anticancer activity has been documented in the literature for several thione derivatives as well as their metal complexes [23][24][25][26]. Specifically thiouracils, being identified as minor components of tRNA [27][28], represent a biologically important sub-class of this extended family of heterocyclic thiones.…”

Design, synthesis and biological evaluation of novel macrocyclic bisbibenzyl analogues as tubulin polymerization inhibitors

“…Microtubules are formed by a dynamic process that involves the polymerization and depolymerization of α and β-tubulin heterodimers. Drugs interfering with this dynamic equilibrium could lead to arrested cell division and eventually to apoptosis [5][6][7][8].…”