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Modern science has made tremendous progress and acquired deep knowledge about Micro-organisms. But still infections caused by these, still ranks very high as a cause of death in the world. Even though there are number of Antibiotics present and new are being developed, the Micro-organisms are developing resistance towards these Antibiotics, hence there is need to find out a better medicine which can contradict all the Micro-organisms. In Ayurveda various formulations are mentioned and well documented, those are having the antimicrobial effect. This is the time to re-establish the effect of antimicrobial agents by proving it clinically or experimentally. Their effect will be evaluated by comparing with the standard drugs (Ciprofloxacin, Ampicillin,) which are in use now. The formulation taken for the study is Bhagottar Gutika. Its antimicrobial study will be done experimentally by adopting cup-plate diffusion method. The study does not require any investigation or intervention to be conducted on patients or animals.

Rasa Shastra basically deals with the pharmaceutics of drugs of mineral and metallic origin. In Rasa Shastra Kupipakwa Rasayana holds an unique importance as compared to other formulations due to its miraculous effects on dreadful and chronic ailments, with rapid action. Kupipakwa Rasayana are well known to be potent because of specific pharmaceutical process, excellent clinical result, long lasting potency and safety even on prolonged use. The Kupipakwa Rasayanas are prepared in especially prepared glass bottle, called as Kupi, by adopting a specially designed instrument, known as Valuka Yantra. Haragouri Rasa is a sublimated mercurial preparation known for its use in different types of Vata-Vyadhi, Rasayana, Vajikarana. Now a days people are more suffering from different types of Vatavyadhi due to different kinds of lifestyle, food habits etc.