Background: Lead (Pb) is a heavy metal that represents an environmental toxicant causing serious health problem. Apigenin (APG) is a plant derived flavonoid with several therapeutic activities. So, the aim of the present study was to determine the protective effect of APG against Pb induced toxicity in cerebella of treated rats. Method: Twenty-four adult male rats (Rattus norvegicus) were used in the present study. They were divided into four groups of six animals per each one as follows: Group I: Rats were daily injected (i.p.) with normal saline as vehicle. Group II: Rats were daily injected (i.p) with lead acetate at a dose of 20 mg/kg b.w. Group III: Rats were daily injected (i.p) with lead acetate at a dose of 20 mg/kg (b.w.) followed by injection (i.p) with APG at dose of 20 mg/kg b.w. Group IV: Rats were daily injected (i.p) with APG at dose of 20 mg/kg b.w. At the end of the four-weeks experimental period, the animals were sacrificed and samples of blood and cerebellar tissue were collected. Results: Lead induced oxidative stress, alterations in levels of studied neurotransmitters, increase in the activities of acetylcholinesterase and increase in the level of the Il-6 and TNF-á and decrease in Il-4 and Il-10 and histological alterations in cerebellum. On the other hand, treatment with APG attenuates these alterations. suggesting that APG might play a neuroprotective role in lead induced neurotoxicity.
Background: Lead (Pb) is an environmental pollutant and has detrimental effects on human health. Apigenin (APG) is a flavonoid that have antioxidant, anti-inflammatory and antiallergic and cardioprotective so is used as treatment of many diseases. The aim of the present study was to evaluate the probable protective effect of APG against Pb-induced toxicity in rats. Methods: Adult male rats were given either Pb (as lead acetate; 20 mg/kg) alone or in combination with APG (20 mg/kg) daily for 4 weeks by intraperitoneally injection (i.p). At the end of the experimental period, Pb accumulation, lipid profile and testicular function alterations were assessed. In addition, histopathological changes in the testis were assessed. Result: Results revealed that Pb treatment significantly increased Pb concentrations in blood and testis of rats. Further, the blood levels of hormones related to testis were altered in Pb-treated rats. In parallel, low sperm count and sperm motility, increased sperm abnormalities and marked pathological changes in testis were observed. On the contrary, the treatment with both Pb and APG recorded amelioration of the deleterious effects of Pb, involving attenuation of changes in lipid profile and testicular hormonal levels, sperm parameters and pathological changes in Pb treated rat’s testis. In conclusion, it appears that dietary APG can ameliorate lead acetate induced hyperlipidemia and hypogonadism in male rats.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.