A series of isatin-P-thiosemicarbazones and isatin-P-hydrazonothiazolines was synthesized by condensation of various isatin derivatives with N4-substituted 3-thiosemicarbazides and cyclization of the products by phenacyl bromides. The products showed high toxicity at lower concentrations when tested for antiviral activity against MDCK cells and did not exhibit antimicrobial activity against various micro-organisms.
Synthese einiger substituierter Isatin-fl-thiosemicarbazone und Isatin-P-hydrazonothiazolin-Derivate als potentielle antivirale und antimikrobielle WirkstoffeEine Serie von Isatin-P-thiosemicarbazonen und Isatin-0-hydrazonothiazolinen wurde synthetisiert durch Kondensation von verschiedenen Isatin-Derivaten mit N4-substituierten-3-thiocarbaziden und Zyklisation der Produkte mit Phenacylbromiden. In niedriger Konzentration zeigten die Verbindungen groRe Toxizitat bei der Testung auf antivirale Wirksamkeit gegen MDCK Zellen. Es konnte keine antimikrobielle Wirkung gegen verschiedene Mikroorganismen festgestellt werden. 03654233/84/080@3701 $ 02.5010
A novel series of 2‐arylthiocarbamoylhydrazino‐5‐phenyl‐1,3,4‐thiadiazoles III‐VII was synthesized and cyclodesulfurized into the corresponding 3‐arylamino‐6‐phenyl‐s‐triazolo[3,4‐b][1,3,4]thiadiazoles VIII‐XII with DCCD. Some of the products were found to be only moderately active against Staphylococcus aureus and Candida albicans.
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