No abstract

No abstract

Postpartum dysgalactia is a common clinical problem for lactating women. Seeking out the safe and efficient phytoestrogens will be a promising strategy for postpartum dysgalactia therapy. In this study, the postpartum mice within four groups, including control group, the model group, and the treatment groups intragastrically administrated with normal saline, bromocriptine, bromocriptine plus 17α-ethinyl estradiol, and bromocriptine plus quercetin, respectively, were used. The results showed that quercetin, a kind of natural phytoestrogen, could efficiently promote lactation yield and mammary gland development in the agalactosis mice produced by bromocriptine administration. Mechanically, quercetin, such as 17α-ethinyl estradiol, significantly stimulated prolactin (PRL) production and deposition in the mammary gland in the agalactosis mice determined by western blotting, quantitative polymerase chain reaction, and enzyme-linked immunosorbent assay, respectively. Furthermore, quercetin could increase the expression of β-casein, stearoyl-CoA desaturase, fatty acid synthase, and α-lactalbumin in the breast tissues that are responsible for the production of fatty acid, lactose, and galactose in the milk at the transcriptional level determined by quantitative polymerase chain reaction. Specifically, quercetin promoted primary mammary epithelial cell proliferation and stimulated prolactin receptor (PRLR) expression probably via AKT activation in vitro. In conclusion, this study indicates that estrogen-like quercetin promotes mammary gland development and lactation yield in milk-deficient mice, probably via stimulating PRL expression and release from the pituitary gland, as well as induces PRLR expression in primary mammary epithelial cells.

BackgroundTo determine the factors affecting the in-hospital prognosis of patients with acute ST segment elevation myocardial infarction (STEMI) after percutaneous coronary intervention (PCI), and to establish its prognostic discriminant model.MethodsA total of 701 consecutive STEMI patients undergoing PCI were enrolled in this study. The patients were divided into two groups, good prognosis and poor prognosis, based on whether the patient had adverse outcomes (death or heart function ≥ grade III) at discharge. Demographic and basic clinical characteristics, diagnosis at admission (e.g., ventricular function, complications, or hyperlipidemia), and biomedical indicators (e.g., blood count, basal metabolism and biochemical composition, blood lipid and glucose levels, myocardial biomarkers, and coagulation) were collected and analyzed.ResultsWe determined 22 factors as risk factors for the in-hospital prognosis of STEMI patients after PCI: age, cardiac function during hospitalization, complications, history of diabetes mellitus, et al., among which the history of diabetes, uric acid, urea nitrogen, and activated partial thromboplastin time (APTT) were independent risk factors.ConclusionWe identified four independent risk factors for the in-hospital prognosis of STEMI patients after PCI and generated a prognostic model to predict the adverse outcomes of these patients.

Objective: To provide basic information and theories for prehypertension early intervention, a systematic analysis of the epidemic status and risk factors among young and middle-aged was carried out here. Methods: This study relied on the data bank of a health check-up population of a class a tertiary general hospital in Guangdong province in 2015. Total 9540 young and middle-aged adults were enrolled, and 733 people were included to find out the effect with lifestyle in these crowd. Principal Components Analysis (PCA) of Factor (FA) was used to identify dietary patterns. The logistic regression model was used to find the risk factors of prehypertension. Results: Among 9540 young and middle-aged cases, the incidence of prehypertension was 36.6%. Moreover, the average age, proportion of male gender, overweight, FBG (fasting blood glucose), dyslipidemia, and hyperuricemia were significantly higher in the prehypertension group than in the optimal BP group. Multivariate logistic regression analysis indicated that age, total cholesterol, triglycerides, uric acid, body mass index and HR (heart rate) were risk factors, and female was a protective factor for prehypertension. Among 733 cases, the incidence of prehypertension was 35.1%. The proportion of smoking, drinking, physical workers, moderate and severe physical activity, and the intake of meat, dietary energy were significantly higher in the prehypertension group than in the optimal BP group. Dietary patterns included “meat model”, “spice model”, “main vegeTables model” and “high protein model”. Multivariate logistic regression analysis indicated that age, drinking were risk factors for prehypertension, while dietary milk intake, dietary magnesium intake were protective factors. Conclusions: Prehypertension is highly prevalent in Guangzhou. However, education about effective lifestyle modifications as an alcohol limit, increasing the intake of dairy products, and magnesium may intervene in the development of prehypertension. But how to develop targeted interventions for such groups need to be further explored. The present study would lay the theoretical foundation and basic data for the next step.