The emerging threat of multi-drug resistance (MDR) in a wide range of diseases is a major public health problem, which prolongs treatment, imposes disabilities and reduces the expected life span. MDR is common in urinary tract infections (UTI). Due to recent dramatic change in antimicrobial activity spectrum, we evaluated the current spectrum of antimicrobials activity in UTIs. We observed 33% infection rate in cultures and positive cultures were followed by the Kirby-Bauer technique for sensitivity testing. We evaluated that females are 3.71 folds more infected than males. We observed Escherichia coli (E. coli) as the most frequent and Pseudomonas aeruginosa (P. aeruginosa) as the least (9.1%). Further, we noted that E. coli infection in males is 4.75 times of males. Moreover, Klebsiella pneumoniae (K. pneumoniae) and E. coli are 2.33 and 7.67 times more prevalent than P. aeruginosa respectively. Our sensitivity results indicate that E. coli and K. pneumoniae are resistant to the most tested antimicrobials. However, P. aeruginosa is susceptible to only few of the tested drugs which include Amikacin, Piperacillin+Tazobactam (in combination), and Ceftriaxone. We conclude, due to MDR strains we need to imitate the current strategies and propose neoadjuvant and other therapies like applied in cancer.