Coronary artery disease (CAD) is the leading cause of death worldwide. Patients with pre-existing CAD were shown to have a more severe course of COVID-19, but this association has not been clarified. We performed a meta-analysis to determine the association between CAD and COVID-19 outcomes. We searched Scopus, Medline (PubMed), Web of Science, Embase, and Cochrane databases up to November 2nd, 2021. There were 62 studies with a total population of 49,286 patients included in the meta-analysis. CAD occurrence in survivor vs. non-survivor groups varied and amounted to 9.2% vs. 22.9%, respectively (OR = 0.33; 95%CI: 0.29 to 0.39; I2 = 70%; p < 0.001). CAD was also associated with increased severity of COVID-19 disease and was (10.8% vs. 5.6%, respectively, for severe vs. non-severe groups (OR = 2.28; 95%CI: 1.59 to 3.27; I2 = 72%; p < 0.001). The role of history of CAD in mortality and severe condition in COVID-19 presents itself as prominent—although a risk of bias in retrospective trials needs to be assessed, in case of our meta-analysis the statistically significant results when it comes to higher mortality among patients with CAD compared to non-CAD patients, a more severe condition observed in patients with CAD, and a visibly more frequent admission to intensive care unit in patients with CAD, it seems that an incidence of cardiovascular events plays a role in COVID-19 prognosis.
Although the novel coronavirus, specifically known as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was thought to primarily affect the respiratory system, with the new studies and cases it seems that an effect on the cardiovascular system may also be prevalent. The manifestations include myocardial injury, exhibited by elevated TnT levels, as well as elevated levels of NT-proBNP and creatine kinase due to already present and now more severe cardiomyopathy or coronary heart disease. In 44,.4% of intensive care unit patients cardiac arrhythmias were reported, although the characteristics of those associated with COVID-19 have not yet been clearly described. In this article we focus on cardiac arrhythmias in COVID-19, which have been associated with underlying myocardial injury and cardiac dysfunction.
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