This study aimed to examine the effect of antibiotic prophylaxis (AP) given within 30 compared to 30–60 min before skin incision on the incidence of infectious morbidity after cesarean delivery (CD). A retrospective cohort study was conducted at a single institution on data between 2014 and 2018. Women who delivered by CD were divided into two groups according to AP timing before skin incision: group 1 within 30 min, and group 2 from 30 to 60 min. The primary outcome was the incidence of any infectious morbidity. Overall, 2989 women were eligible: 2791 in group 1 and 198 in group 2. The primary composite outcome occurred in 125 women (4.48%) in group 1 and 8 women (4.04%) in group 2 (OR, 1.11; 95% CI 0.54–2.31; P = 0.77). The rate of surgical site infection only, was 1.08% in group 1 and 0.51% in group 2 (OR, 2.13; 95% CI 0.29–15.70; P = 0.72). The incidence was comparable between the groups in a separate sub-analysis restricted to laboring CDs and obese women. The rate of infectious morbidity was similar among women who received AP within 30 min and from 30 to 60 min before skin incision.
Objective
The coronavirus disease 2019 (COVID‐19), caused by severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2), ranges from asymptomatic to severe infection. We aimed to compare the prevalence of COVID‐19 in asymptomatic pregnant vs. non‐pregnant women in order to establish recommendations for a COVID‐19 screening strategy.
Methods
A prospective multicenter cohort study was conducted. Asymptomatic pregnant or non‐pregnant women after March 2020 (the time when COVID‐19 was first detected in north Israel) were tested for SARS‐CoV‐2 using nasopharyngeal reverse‐transcription polymerase chain reaction test, anti‐nucleocapside‐IgG and anti‐spike‐IgG. Diagnosis was made if at least one test was positive. Pregnant women were tested between 34‐42 weeks, mostly at birth.
Results
Among the 297 participating women, 152 were pregnant and 145 were non‐pregnant. The prevalence of asymptomatic COVID‐19 was similar between the groups (4 (2.6%) and 8 (5.5%), respectively, p=0.2). All women with COVID‐19 delivered at term, healthy appropriate‐for‐gestational‐age babies without malformations.
Conclusions
The rate of asymptomatic COVID‐19 in pregnant women is low and comparable to the rate among non‐pregnant women. Pregnancy outcomes are favorable. Future screening programs should consider that 1 of 25 screened asymptomatic women will be positive.
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