[reaction--see text] A simple method for determining the absolute configuration of chiral alcohols with a unique chromophoric reagent 1 based on induced exciton chirality has been developed. Practical usefulness of the present method was demonstrated by the determination of the absolute configuration of 17,18-dihydroxybergamottin.
In the presence of AlCl3, trimethylsilyl cyanide underwent 1,4- and subsequent 1,2-additions with α,β-unsaturated imines to give 2-aminopentanedinitriles in good yields. An asymmetric version of this type of bis-cyanation was successfully conducted using a chiral α,β-unsaturated imine possessing a phenylglycinol derivative as a chiral auxiliary.
In the presence of AlCl3, a mixture of ketene silyl (thio)acetal and trimethylsilyl cyanide underwent 1,4- and subsequent 1,2-addition, respectively, with α,β-unsaturated imines to give ethyl(S-alkyl) 5-amino-6-cyanopentanoates in good yields.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.