Objectives: The aim of study is to find out the role of chromium with biological antioxidant and how these can relate with the health of fiber glass workers. Study Design: Cross Sectional Study. Setting: Fiber glass industry Lahore. Period: July 2018 to Feb 2019. Material & Methods: Study was included the fifty workers of fiber glass industry with 4-5 years experience or time of exposure. A questionnaire was filled by each participant. Twenty individuals were taken as controls. Their blood sample was drawn to estimate the level of chromium and of biological antioxidants that include serum Catalase, Superoxide Dismutase, Glutathione and Malondialdehye. Results: Mean age of workers was 35 year with BMI 23.80 kg/m2. Their work duration in Fiber glass factory was 6-7 years. Levels of serum chromium and the biological antioxident was significantly high (P<0.001) in fiber glass workers as compared to the levels of these parameters of control. A positive weak correlation was observed between serum chromium and antioxidants MDA, SOD and catalase. On the other hand a moderate inverse correlation was observed between serum chromium and antioxidant GSH. Conclusion: It is concluded that high level of chromium in workers of fiber glass factory is responsible for increased levels of antioxidants in their body, which in long run may develop the diseases especially of respiratory tract.
Objective: To find the probable role of Homocysteine as a prognostic indicator for women with Pregnancy-Induced Hypertension and comparison of Homocysteine Levels in Normal Versus pre-eclamptic women. Study Design: Cross Sectional Comparative study. Setting: Gynecology Unit of Lahore General Hospital, Lahore. Period: May 2017 to Oct 2017. Material & Methods: Thirty four consented pre-eclamptic pregnant women with age range 29 to 35 years were included in the study. 20 age matched pregnant women with no history of any clinical problem were taken as controls. A questionnaire based on age, obstetric details including detail of gravida, family history etc was filled by both subjects and controls. Anthropometric parameters were noted based on height and weight. Blood sample of both patients and controls was drawn for estimation of blood urea, serum creatinine, and homocysteine. Results: Mean age of women was 31 year with BMI 27.0 Kg/m2. Levels of serum homocysteine were significantly more women with pre-eclampsia in comparison with cases of controls. However the values of blood urea and serum creatinine were insignificantly high in pre-eclamptic women in comparison with their controls. Conclusion: Serum homocysteine as a biomarker may help to find out its additive importance in the prediction of pre-eclampsia and the severity of its related complications.
Background: Controversy occurs in the relationship between serum ferritin levels, insulin resistance and risk of developing anemia in adolescents with family history of diabetes.
Aims & Objectives: This study was designed to find out the association between serum ferritin levels with risk of developing anemia in non-diabetic adolescents with family history of type 2 diabetes mellitus (T2DM).
Materials & Methods: A descriptive cross-sectional was conducted in a local medical institute of Lahore. Study included 50 non-diabetic, non-obese male / female adolescent with family history of type 2 diabetes mellitus and 50 healthy male/female non-obese adolescents without family history of T2DM considered as controls. Level of serum ferritin and serum insulin was estimated by Enzyme Linked Immunosorbent Assay. Blood glucose was estimated by auto-analyzer. Insulin resistance was calculated by HOMA-IR index and beta cell function was assessed by HOMA- beta index.
Results: Levels of fasting blood sugar, insulin resistance were found to be increased with decreased level of serum ferritin and decrease beta cell function in both male as well as female cases as compared to controls. Negative correlation was found between serum ferritin and insulin resistance while a positive correlation was found between serum ferritin and beta cell function.
Conclusions: Low level of serum ferritin is associated with reduced beta cell function and increased insulin resistance. This may increase the risk of developing iron deficiency anemia that can affect both immune system as well as increase susceptibility to infections.
Background: In response to oxidative stress, reactive oxygen species aggravate and activate different signaling mechanism and stimulate the release of different inflammatory mediators, and provoke the generation of oxidative stress, all of which can promote the development of acute coronary syndrome. Methodology: The study sample comprised of 76 ACS patients and 76 healthy controls. Blood samples of ACS patients and controls were collected to determine the serum concentration of antioxidants, and the serum levels of inflammatory biomarkers. Spectrophotometric method and ELISA kit method was used to measure these variables accordingly. Results: The results indicated a significant rise in the levels of IL-1, IL-6, IL-8, TNF-α, MMP-11, ICAM-1 and VCAM-1 in ACS patients compared to controls whereas significant decrease was recorded in GSH, CAT, SOD, GRx and HDL levels in patients with ACS compared to controls. Conclusion: The present study indicated that the increased serum concentration of inflammatory cytokines and antioxidant reduction may influence the pathogenesis of ACS. Keywords: Acute coronary syndrome, oxidative stress , antioxidants
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