Objectives: The purpose of this study is investigating curcumin role in mood alterations in male rats after spinal cord injury through focusing on the involvement of NLRP3 inflammasome.
Methods: Fourteen adualt male Wistar rats (220–250 g) were divided to five animal groups (n = 8 per group): Control: healthy animals which received normal saline for 14 days; spinal cord injury: spinal cord injury-induced animals which received normal saline for 14 days; spinal cord injury + curcumin (20, 40, and 80 mg/kg/ i.p): spinal cord injury-induced animals treated with 3 doses of curcumin for 14 days. To assess the mood of animals, the elevated plus maze test, forced swimming test, tail suspension test, and open field test were performed. Graph-pad prism software was used for data analysis. Statistical analysis was done by one-way ANOVA with Tukey’s post hoc test. P < 0.05 was statistically significant.
Results: Treatment with curcumin with two doses of 40 and 80 mg/kg increased open arm time and decreased close arm time as compared to the spinal cord injury group. The administration of curcumin (40 mg/kg and 80 mg/kg) enhanced the altered behaviors. Spinal cord injury caused an increase in the protein levels NLRP3, ASC and Casp1 in the hippocampus of animals as compared to the sham group. Curcumin regulated the protein levels of NLRP3, ASC and Casp1 in the hippocampus of animals.
Conclusion: Depression is prevalent in person with spinal cord injury and our findings indicated that curcumin appears to constitute a suitable agent to reduce neuroinflammation and through it, relieve a depressive-like state.
To overcome COVID-19 long-term consequences, one possible approach is to control inflammasomes activation, because SARS-CoV-2 can induce humoral and cellular immune responses. In this opinion article we hypothesized that if it is proven with convincing and unmistakable evidence that firstly, SARS-CoV-2 can enter cells and damage them through its common receptors in the reproductive tissues, and secondly, inflammasome pathway activation is responsible for the damages caused, then the inflammasome inhibitors might be considered as suitable candidates in preventing the pathological effects on the germ cells and reproductive tissues and subsequent fertility.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.