Effect of Aqueous Extract of Ruta graveolens on Spermatogenesis of Adult Rats

Bazrafkan, Mahshid; Panahi, Mitra; Saki, Ghasem; Ahangarpour, Akram; Zaeimzadeh, N.

doi:10.3923/ijp.2010.926.929

Cited by 12 publications

(6 citation statements)

References 11 publications

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“…Reduction in the levels of testosterone, luteinizing hormone (LH) and follicle-stimulating hormone (FSH) was reported when the crude methanol extract of medicinal plant was administered to male albino rats[ 4 5 ]. Administration of the methanol extract of Sarcostemma acidum at a dose of 100 mg to male albino rats for 60 days caused a decrease in the number of mature Leydig cells and an increase in the degeneration of Leydig cell population[ 6 ].…”

Section: Introductionmentioning

confidence: 99%

The potentiality of medicinal plants as the source of new contraceptive principles in males

et al. 2011

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Rising human population throughout the world especially in developing and underdeveloped countries has detrimental effects on life supporting system on earth. Traditionally, plants have been used to treat different kinds of ailments. The growing importance of phytochemicals in males has been reported. Contraceptive ability of plants has been reported in several animal models. The reversibility of the anti-fertility effects of plants and its active compounds are of potential clinical relevance in the development of male contraceptive. This review attempts to discuss the latest reports on the potentiality of medicinal plants as the source of new contraceptive principles in males.

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Section: Introductionmentioning

confidence: 99%

The potentiality of medicinal plants as the source of new contraceptive principles in males

et al. 2011

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“…A separate study will be required to elucidate on the active principle responsible for this effects. Other workers have reported similar results in testicular weight reduction accompanied by decreased serum testosterone levels, impaired spermatogenesis and a decrease in sperm parameters in a dose dependent manner in male rats treated with other plants (Raji and Bolarinwa 1997;Raji et al, 2003;Chaturvedi et al, 2003;Pankajakshy and Madambath, 2009;Bazrafkan et al, 2010).…”

Section: Discussionmentioning

confidence: 55%

Effect of aqueous leaf extracts of Leptadenia hastata Pers (Decne) on spermiogram and testicular histology in albino rats (Wistar strain)

Maina¹,

Peter²,

Yahi³

et al. 2018

J. Med. Plants Res.

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This study was designed to determine the effects of prolonged oral administration of aqueous leaf extract of Leptadenia hastata Pers (Decne) on sperm concentration, sperm motility and testicular histology in Wistar rats. Rats were given graded doses (200, 400, 600 and 800 mg kg -1 ) of aqueous leaf extract of L. hastata orally for 28 days. Weekly changes in sperm concentration and motility as well as testicular weight and histology were monitored. Sperm concentration, motility and testicular weights did not show significant change (p>0.05) among the groups, but a significant difference (p<0.05) exist between control group and the group that had the highest dose (800 mg/kg) of L. hastata. Histopathological studies revealed marked depletion of spermatozoa in the testes and epididymis of rats that received 800 mg/kg of L. hastata. Prolonged administration of aqueous leaf extract of L. hastata at 800 mg/kg caused a reduction in total sperm concentration, sperm motility and a reduction in testicular weight in rats.

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“…Much research has recently been focused on the anti-fertility effect of plant extracts, especially on the male contraceptive effects of such extracts [ 1 ]. These effects may be assessed in a number of ways.…”

Section: Discussionmentioning

confidence: 99%

“…Population control is one of the most important issues in global health, and extensive research in the field of male contraception is being carried out [ 1 ]. Some studies on plants that have a history in use in traditional medicine, such as the grape, have suggested that these plants may negatively affect fertility in men.…”

Section: Introductionmentioning

confidence: 99%

The Effect ofVitis viniferaL. Juice on Serum Levels of Inhibin B, Sperm Count in Adult Male Rats

Afzalzadeh

Ahangarpour

Amirzargar

et al. 2015

World J Mens Health

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PurposeVitis vinifera is a species of Vitis that is native to the Mediterranean region, central Europe, and southwestern Asia, and has been used as a drug in traditional medicine. Traditional medicinal plants have been used for medical purposes with increasing effectiveness. It is important to identify drugs that inhibit spermatogenesis. Therefore, the present study aimed to investigate the effect of grape juice (GJ) on serum levels of inhibin B and sperm count in normal male rats.Materials and MethodsThirty-five adult male rats were randomly divided into five groups, each containing seven rats. Rats in the control group received 1 mL of normal saline over the course of the study. The experimental groups received GJ (100, 200, 400, and 1,600 mg/kg, orally, for 35 days consecutively). At the end of the treatment period, fertility indices were measured, including body weight difference, sex organ weight, sperm motility and count, epididymal sperm reserve, daily sperm production (DSP), and serum inhibin B levels.ResultsWe found that GJ reduces body weight difference, was associated with decreased sperm motility and count in all treatment groups (p≤0.05 and p≤0.001, respectively). Moreover, DSP was significantly decreased in all treatment groups compared to the control group (p≤0.05), except in the group receiving 100 mg/kg of GJ. Inhibin B levels were significantly decreased in all treatment groups (p≤0.05).ConclusionsThe results of our study suggest that GJ in all doses, but especially in higher doses, may decrease fertility in male rats.

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Effect of Aqueous Extract of Ruta graveolens on Spermatogenesis of Adult Rats

Cited by 12 publications

References 11 publications

The potentiality of medicinal plants as the source of new contraceptive principles in males

The potentiality of medicinal plants as the source of new contraceptive principles in males

Effect of aqueous leaf extracts of Leptadenia hastata Pers (Decne) on spermiogram and testicular histology in albino rats (Wistar strain)

The Effect ofVitis viniferaL. Juice on Serum Levels of Inhibin B, Sperm Count in Adult Male Rats

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