In recent years, ginger has become a subject of interest because of its beneficial effects on human health. The purpose of the present study was to investigate the effects of daily oral administration of ginger extract for 6 weeks on plasma glucose, lipid profile and kidney functions in alloxan-induced diabetic rats to show the ameliorating and partly curative effects in alloxan induced-diabetic rats (150 mg/kg i.p.(Intrapretonial). Rats (130-150gm) were divided into 4 groups; normal control rats, diabetic control rats, diabetic rats post-treated with ginger and diabetic rats pretreated with ginger. Ginger extract was administered orally for 6 weeks to post-treated and pre-treated rats, and they were compared with the normal and diabetic groups, respectively. Plasma glucose was reduced significantly in both post-treated and pretreated groups. The post-treatment with ginger extract reduced plasma cholesterol, triglyceride and LDL-cholesterol, but during the pre-treatment with ginger extract produced insignificant change only in plasma triglyceride level. The plasma HDLcholesterol was significantly increased in post-treated and pre-treated groups. The plasma creatinine, urea and uric acid levels were significantly reduced in post-treated group; also in pre-treated group, they were reduced but urea level statistically did not change. It is concluded that the consumption of ginger produced a significant hypoglycemic effect in diabetic rats. In addition, ginger is capable of improving hyperlipidemia and the impaired kidney functions in alloxan-induced diabetic rats.
In recent years, green tea has become a subject of interest because of its beneficial effects on human health. The purpose of the present study was to investigate the effects of daily oral administration of green tea extract for 6 weeks on plasma glucose, lipid profile and kidney functions in alloxan-induced diabetic rats to show the preventive and curative effects of green tea.Rats (130-150 g) were divided into 4 groups, normal control rats, diabetic rats, diabetic rats post-treated with green tea and diabetic rats pretreated with green tea. Green tea extract was administered orally for 6 weeks to the third and forth groups (300 mg/kg b.w,). Plasma glucose, triglycerides, HDL and LDL-cholesterol were significantly reduced in post-treated and pre-treated groups while plasma cholesterol was significantly reduced only in post-treated group while plasma creatinine, urea and uric acid levels were significantly reduced in post-treated diabetic group, but in the pre-treated group creatinine and uric acid levels were reduced, but urea level did not change. It is concluded that the consumption of green tea produced a significant reduction in glucose level in diabetic rats. In addition green tea is capable of improving hyperlipidaemia and the impaired kidney functions in addition to its hyperglycemic control.
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