Effect of Ginger Extract Consumption on levels of blood Glucose, Lipid Profile and Kidney Functions in Alloxan Induced-Diabetic Rats.

Elshater, Abd-Elraheem A.; Salman, Muhammad; Moussa, Mahrous M. A.

doi:10.21608/eajbsa.2009.15515

Cited by 33 publications

(33 citation statements)

References 22 publications

(26 reference statements)

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“…Induction of Diabetes to animals by alloxan monohydrate often shows elevated triglyceride and cholesterol levels [29] and reduced HDL-cholesterol values [30]. Similarly in this study the lipid parameters were performed where diabetic control animals showed higher triglycerides and cholesterol levels and lower HDL-cholesterol values which when treated with standard drug and test extracts resulted in lowered serum cholesterol and serum triglyceride levels and an increase in the HDL-cholesterol level.…”

Section: Discussionmentioning

confidence: 78%

Evaluation of Anti-Hyperglycemic Activity of Adiantum Philippense Linn, a Pteridophyte in Alloxan Induced Diabetic Rats

Paul¹

2012

J Diabetes Metab

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Nowadays, Tolbutamide, Metformin, Gliclazideetc that are highly preferred as anti-diabetic drugs are mainly sulfonylureas and biguanides which are known to cause various adverse effects [4]. Hence in the recent years medicinal plants have become a subject of interest for drug development owing to their phytochemical constituents and their therapeutic potential. In particular, the angiosperms are given more emphasis but the pteridophytes which are significant group of plant kingdom with 12000 species are not much studied for their antidiabetic activity. Adiantum philippense Linn is commonly known as 'Hanspadi' or 'Walking Maiden hair fern'. It is widely distributed in many parts of India and used as an ornamental plant. It is ethnomedicinally used in bleeding diseases, burning sensation, erysipelas, epileptic fits, dysentery, and elephantiasis [5]. It has been reported that the dried whole plant has been used as a medicine for bronchitis and cough [6]. Adiantum philippense is also reported to have anti-bacterial [7] and anti-fungal activity [8]. Adiantum capillus veneries, a fern of the same genus as that of Adiantum philippense Linn possess antidiabetic potential which is marketed with brand name "Avenca TM ". Belonging to the same genus and family of Pteridophytes, insufficient information was available regarding anti diabetic potential of Adiantum philippense Linn (Adiantum lunulatum Burm f.) which led us to investigate its antihyperglycemic potential on alloxan induced diabetic rats. Materials and Methods Collection and authentication The fern Adiantum philippense Linn (AP) was collected from ChandraprabhaVanrai, Dapoli in the Ratnagiri district of Maharashtra in the end of monsoon and was authenticated by Dr. P.

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Section: Discussionmentioning

confidence: 78%

Evaluation of Anti-Hyperglycemic Activity of Adiantum Philippense Linn, a Pteridophyte in Alloxan Induced Diabetic Rats

Paul¹

2012

J Diabetes Metab

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“…In another study, intraperitoneal administration of aqueous extracts of ginger at three different doses was associated with hypoglycemic effects in diabetic rats in a dose-dependant manner (Ozougwu & Eyo, 2011). Elshater et al (2009) also demonstrated that post-treatment and pre-treatment with the ginger extract reduced plasma glucose levels in type one diabetic rats. Moreover, hypolipidemic effect of ginger was mentioned in this study.…”

Section: Discussionmentioning

confidence: 82%

“…There are some scientific evidences on the effects of ginger on the blood levels of glucose and lipids (Bhandari & Pillai, 2005;Elshater et al, 2009). Al-Amin et al (2006) reported hypoglycaemic and hypolipidemic potentials of ginger at a dose of 500 mg/kg in the streptozotocin-induced diabetic rats.…”

Section: Introductionmentioning

confidence: 99%

Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients

Mahluji¹,

Attari²,

Mobasseri³

et al. 2013

International Journal of Food Sciences and Nutrition

132

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The present study was aimed to evaluate the effects of Zingiber officinale on some biochemical parameters in type 2 diabetic (DM2) patients. In a randomized double-blind placebo controlled trial, 64 patients with DM2 were assigned to ginger or placebo groups (receiving 2 g/d of each). A 3 d diet record, anthropometric measurements and concentrations of fasting blood glucose (FPG), HbA1c, lipid profile (including total cholesterol, triglyceride, low density lipoprotein and high density lipoprotein) and also the homeostasis model assessment (HOMA) and quantitative insulin-sensitivity check index (QUICKI) were determined before and after 2 months of intervention. Ginger supplementation significantly lowered the levels of insulin (11.0 AE 2.3 versus 12.1 AE 3.3; p ¼ 0.001), LDL-C (67.8 AE 27.2 versus 89.2 AE 24.9; p ¼ 0.04), TG (127.7 AE 43.7 versus 128.2 AE 37.7; p ¼ 0.03) and the HOMA index (3.9 AE 1.09 versus 4.5 AE 1.8; p ¼ 0.002) and increased the QUICKI index (0.313 AE 0.012 versus 0.308 AE 0.012; p ¼ 0.005) in comparison to the control group; while, there were no significant changes in FPG, TC, HDL-C and HbA1c (p40.05). In summary, ginger supplementation improved insulin sensitivity and some fractions of lipid profile in DM2 patients. Therefore it may be considered as a useful remedy to reduce the secondary complications of DM2.

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“…Further steps were done to get extract with a concentraion of 1g/ml taking in consideration the starting weight of the plant. The method illustrated by Elshater et al, (2009) was used to prepare the extract. Fifteen healthy adult female albino rats were purchased from the faculty of medicine, University of Jordan.…”

Section: Methodsmentioning

confidence: 99%

The Histological Effect of Aqueous Ginger Extract on Kidneys and Lungs of Diabetic Rats

Al-Qudah¹,

Al-Ramamneh²,

Haddad³

et al. 2018

IJB

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Diabetes is a disorder affecting various-aged humans and which can with time cause serious problems for the patient. Medicinal plants are known for their hypoglycemic effects; and among which is ginger (Zingiber officinale) known also for its culinary uses. This study, therefore, was undertaken to evaluate the histological effect of 21-day treatment of aqueous ginger extract used at 500 mg / kg BW on female diabetic rats. Fifteen female albino rats were divided into three groups; Group I: control, Group II: non-treated diabetic, and Group III: ginger extract-treated diabetic rats. The ginger extract-treated diabetic group received the daily dose orally for three weeks. Results show that organ weight was not significantly changed. Light microscopic examination of 5µm sections of extract-treated Kidney and Lung of the diabetic rats revealed approximately normal histological structure compared with the untreated ones. The normal appearance of glomeruli and alveoli as well as the normal alveolar wall assumed the ameliorative effect ginger aqueous extract could have on kidney and lung of diabetic rats. These results indicated that this dose of ginger extract may be effective in the treatment of diabetic rats.

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Effect of Ginger Extract Consumption on levels of blood Glucose, Lipid Profile and Kidney Functions in Alloxan Induced-Diabetic Rats.

Cited by 33 publications

References 22 publications

Evaluation of Anti-Hyperglycemic Activity of Adiantum Philippense Linn, a Pteridophyte in Alloxan Induced Diabetic Rats

Evaluation of Anti-Hyperglycemic Activity of Adiantum Philippense Linn, a Pteridophyte in Alloxan Induced Diabetic Rats

Effects of ginger (Zingiber officinale) on plasma glucose level, HbA1c and insulin sensitivity in type 2 diabetic patients

The Histological Effect of Aqueous Ginger Extract on Kidneys and Lungs of Diabetic Rats

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