Background:
Periodontal disease is the most common oral condition that affects the tissue
surrounding the teeth. The oral cavity is colonized by an impressive array of micro-organisms, many of
which can colonize the implants such as Guided Tissue Regeneration (GTR) often utilized in recovering
procedures that result in inflammation interfering with the bone regeneration.
Methods:
In the current study, a nano-hybrid GTR membrane is developed as a heliacal structure scaffold
with localized drug delivery function (Ibuprofen) as an anti-inflammatory agent. Polycaprolactone
(PCL) and a blend of Polyvinyl alcohol (PVA)/collagen (Col) (50/50) were electrospun by electrospinning.
Ibuprofen (Ibu) was loaded once in the PCL context and once in the hydrophilic portion
(PVA/Col).
Results:
The in vitro release behavior was investigated in each case. Chemical and physical properties
were studied for each item. Morphology investigation indicated a heliacal structure with the total average
diameter of 1266 nm consististing of porous pores with the average diameter of 256nm.
Conclusion:
The membranes indicated proper mechanical properties and appropriate biodegradation
rate as a potential GTR membrane. The controlled and sustained release of Ibu was obtained from both
PCL and PVA/COL loaded membranes. Kinetic model study indicated the following zero-order and
Higuchi models for the optimum case of PCL loaded and PVA/Col Ibu loaded scaffolds respectively.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.