No abstract

Some single nucleotide polymorphisms and their combinations in the Ugrp2 gene are associated with an increased risk of developing adenoid hypertrophy. Therefore, we tried to underline the importance of genetic factors associated with adenoid hypertrophy and its related clinical phenotypes.

Background/aim: Adenoid hypertrophy (AH) is chronic enlargement of the adenoid tissue. The pathophysiology of the disease is unclear. We analyzed SCGB1D4 gene polymorphisms in order to determine the effect of the variants or their genetic combinations on AH. Materials and methods:We genotyped the SCGB1D4 (IIS) gene in 167 participants (95 children with AH and 72 controls) by performing DNA sequencing in blood samples. Results:We genotyped three single nucleotide polymorphisms (SNPs). In the analysis, we found that in the presence of those SNPs and the minor alleles of individual SNPs four haplotypes were associated with an increased risk of AH. In addition, those SNPs were significantly associated with asthma, allergy, sleep-disordered breathing, AH grade +4, and a high level of IgE. As indicated on multifactor dimensionality reduction analysis, single-locus (rs35328961), two-locus (rs35328961_rs56196602), and three-locus models (rs200327820_rs35328961_rs56196602) had the highest synergistic interaction effect on AH. The three-factor model was also significantly associated with some genotypes of rs35328961 and allergic-asthmatic AH. Conclusion:SNPs of SCGB1D4 and their combinations are associated with an increased risk for developing AH. We highlighted the importance of genetic factors on AH and AH-related clinical phenotypes.

Objective:The purpose of this study was to observe and evaluate the possible complications of Transoral Endonasal-Controlled Combined Endoscopic Adenoidectomy (TECCA) as a subtype of power-assisted endoscopic adenoidectomy (PAEA) in pediatric patients.Methods: Sixty-seven children aged between 2 and 12 years who had been diagnosed with adenoid hypertrophy and underwent TECCA from April 2013 to December 2016 as a single procedure (without myringotomy or any kind of tonsil surgery at the same time) were included. Preoperative risk assessment results and intraoperative and post-operative complications were evaluated.Results: Intraoperative and early post-operative bleeding was observed in four (5.97%) patients. There was no post-operative complication except for bleeding and no patients were found to have residual adenoid tissue during the six-month post-operative follow-up period. Conclusion:Endonasal endoscopic control during adenoidectomy helps to identify vascular structures that would normally be at risk of being injured with blind resection. Endoscopic viewing also enables complete removal of intranasal adenoid tissue without significant prolongation in operation time.

azal septal cisim, nazal septumun ön üst kısmında, internal nazal valf bölgesinde, kartilaj ve kemik septum boyunca uzanan, rutin anterior rinoskopide, endoskopik muayenede ve görüntüleme tetkiklerinde mukozal şişkinlik olarak görülebilen yumuşak doku kitlesidir. 1 Septal cismin yapısı ve fonksiyonları konusundaki bilgiler sınırlı olmakla