Association of Ugrp2 gene polymorphisms with adenoid hypertrophy in the pediatric population

Atilla, Mahmut Huntürk; Özdaş, Sibel; Özdaş, Talih; Baştimur, Sibel; Muz, Sami̇ Engi̇n; Öz, Işılay; Kurt, Kenan; İzbırak, Afife; Babademez, Mehmet Alı; Vatandaş, Nilgün

doi:10.1016/j.bjorl.2017.07.004

Cited by 7 publications

(4 citation statements)

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“…Интересно, что другие исследования показали, что полиморфизм rs1800896 в гене IL-10 может быть Бронхопульмонология и отоларингология связан с заболеваемостью ВЭБ и вирусом, ассоциированным с гемофагоцитарным лимфогистиоцитозом (ВЭБ-ГЛГ) у детей, а генотип АА и аллель А могут быть чувствительными факторами риска для ВЭБ-ГЛГ [50]. Кроме того, в предыдущих работах было показано, что полиморфизм гена MBL2 (SNP 49 C/T rs5030737) [23], генотипы AG + GG и AG по TLR4-D299G [51], Ugrp2 [52], генотипы 2R, 2R, IL-1Ra и T и T IL-1b [53] были связаны с повышенным риском развития ГГМ. Наши результаты позволяют предположить, что генотип GG по IL-10 rs1800896 играет роль в устойчивости к ГГМ и может предотвращать разрастание ткани глоточной миндалины до максимального размера.…”

Section: Discussionunclassified

<i>G-1082A</i> IL-10 polymorphism as a predictor of adenoid hypertrophy in children with human herpes virus

et al. 2023

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Introduction. Adenoid hypertrophy (pharyngeal tonsil hypertrophy) is considered as one of the most common diseases of the ENT organs.Aim. To study the polymorphism of the IL-10 gene (interleukin 10) and infections caused by human herpesvirus 6 (HHV6), cytomegalovirus (CMV) and Epstein-Barr virus (EBV) in children with AH.Materials and methods. The study included 106 children with adenoid hypertrophy and 38 healthy children aged 2 to 11 years. All children with adenoid hypertrophy were divided into three subgroups depending on the size of the pharyngeal tonsil. Viruses were determined by real-time quantitative polymerase chain reaction (PCR).Results. In patients with AH, HHV6 was detected more often than in CMV and EBV. Among the three subgroups of children with HGM, HHV6 and EBV infections prevailed in children with the maximum degree of pharyngeal tonsil hypertrophy. The frequency of the GG genotype was higher in the control group of children. Significantly higher frequencies of the G allele and GG and GA genotypes for IL-10 rs1800896 were found in the subgroup of children with the smallest size of the pharyngeal tonsil compared to other subgroups.Discussions. The frequencies of HHV-6 and CMV in the control group are significantly different. HHV-6 was the most frequently detected virus in patients with HGM compared with CMV and EBV. The frequency of the GG genotype was in the control group of children. A significantly higher frequency of the G allele and GG genotypes was found in the first subgroup of children compared to the second and exclusive subgroups. We found a lower frequency of the G allele and GG and GA genotypes in a significant subgroup of children compared to the second subgroup. Previous studies show a significant increase in the frequency of the A allele and the AA and IL-10 genotypes (rs1800896-1082G/A) in patients resistant to HHV-6 and CMV infections compared to those infected.Conclusions. The presence of HHV-6 and CMV infections contributes to the development of pharyngeal tonsil hypertrophy, and HHV-6 and EBV may contribute to the size of the pharyngeal tonsil.

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Section: Discussionunclassified

<i>G-1082A</i> IL-10 polymorphism as a predictor of adenoid hypertrophy in children with human herpes virus

et al. 2023

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“…Interestingly, other studies showed that the polymorphism of rs1800896 in the IL-10 gene may be related to the incidence of EBV and Epstein-Barr virus associated with hemophagocytic lymphohistiocytosis (EBV-HLH) in children, and the AA genotype and A allele of both sites may be the susceptible risk factors for EBV-HLH [38]. Furthermore, prior works showed that the MBL2 (SNP 49 C/T rs5030737) gene polymorphism [24]; the AG + GG and AG genotypes at TLR4-D299G [39]; Ugrp2 [40]; and the 2R, 2R, Il-1Ra and T, and T IL-1b genotypes [41] were associated with an increased risk of developing adenoid hypertrophy. Our results suggested that genotype GG for IL-10 rs1800896 played a role in the resistance to adenoid hypertrophy and could prevent the expansion of the adenoid tissue to the maximum size.…”

Section: Discussionmentioning

confidence: 99%

Adenoid Hypertrophy Risk in Children Carriers of G-1082A Polymorphism of IL-10 Infected with Human Herpes Virus (HHV6, EBV, CMV)

Lomaeva

Aghajanyan

Dzhaparidze³

et al. 2022

Life

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Adenoid hypertrophy (AH) is considered one of the most common diseases in the ear, nose and throat (ENT) practice. The cause of adenoid hypertrophy in children is still unknown. The main aim of the current study was to investigate IL-10 (interleukin 10) gene polymorphisms and human herpesviruses 6 (HHV6), cytomegalovirus (CMV), and Epstein–Barr virus (EBV) infections in children with AH. A total of 106 children with adenoid hypertrophy and 38 healthy children aged 2–11 years were included in this study. All children with adenoid hypertrophy were divided into three subgroups depending on the adenoid size. The viruses were determined via quantitative real-time polymerase chain reaction (PCR) using commercially available kits (QIAGEN, Germany). HHV6 was more frequently detected in patients with AH compared with CMV and EBV. Among the three subgroups of children with AH, HH6 and EBV were prevalent in the children with the largest adenoid size. The frequency of genotype GG tended to be higher in the control group of children. We found significantly higher frequencies of the G allele and GG and GA genotypes for IL-10 rs1800896 in the subgroup of children with the smallest size of adenoid compared with other subgroups. In conclusion, HHV6 and EBV infection could contribute to the adenoid size. The genotype GG for IL-10 rs1800896 could contribute to the resistance to adenoid hypertrophy and the spread of the adenoid tissue.

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“…Similarly, NACHT LRR and PYD domains-containing protein 3 (NLRP3)-mediated pyroptosis has been shown to be a mechanism through which IL-32 influences the progression of AH [82]. Additionally, a higher chance of developing AH has also been linked to several genetic predisposing factors [83][84][85][86]. However, in a recent study conducted in Moscow, Lomaeva et al suggested that children aged 2-11 years with the IL-10G-1082A genotype GG might be resistant to the development of AH [47].…”

Section: Aetiological Agents For Ah and Npcmentioning

confidence: 99%

The Link Between Adenoids and Nasopharyngeal Carcinoma

Asante¹,

Akakpo²,

Wiafe³

2023

Tonsils and Adenoids

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Adenoids, play a significant role in inflammatory response, especially in children. Together with other tissues of the lymphatic system, it fights off infections. In most cases of nasopharyngeal cancer, though rare, other histopathological variants of adenoids are seen. Adenoid hypertrophy is mostly observed, which causes obstruction of the nasopharynx and dysfunction of the Eustachian tube because of the formation of an abnormal tissue mass. Different viral and bacterial pathogens are associated with adenoid hypertrophy, including Epstein-Barr virus (EBV), coronavirus, parainfluenza virus, Mycoplasma pneumoniae, Staphylococcus aureus, and Neisseria gonorrhoeae. Among these, EBV is associated with both adenoid hypertrophy and nasopharyngeal cancer, indicating the effect of EBV on both nasopharyngeal cancer and adenoids. We critically appraise the current evidence and discuss potential link between adenoids and nasopharyngeal carcinoma.

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Association of Ugrp2 gene polymorphisms with adenoid hypertrophy in the pediatric population

Abstract: Some single nucleotide polymorphisms and their combinations in the Ugrp2 gene are associated with an increased risk of developing adenoid hypertrophy. Therefore, we tried to underline the importance of genetic factors associated with adenoid hypertrophy and its related clinical phenotypes.

Cited by 7 publications

References 35 publications

<i>G-1082A</i> IL-10 polymorphism as a predictor of adenoid hypertrophy in children with human herpes virus

<i>G-1082A</i> IL-10 polymorphism as a predictor of adenoid hypertrophy in children with human herpes virus

Adenoid Hypertrophy Risk in Children Carriers of G-1082A Polymorphism of IL-10 Infected with Human Herpes Virus (HHV6, EBV, CMV)

The Link Between Adenoids and Nasopharyngeal Carcinoma

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