Background: Oocyte maturation begins at the embryonic stage and continues throughout life. The effect of Follicle- Stimulating hormone (FSH) on gene of genes was evaluated using GEO access codes for the data set GSE38345. Materials and Methods: The microarray data containing the gene expression information from cow oocytes show that their maturation is influenced by FSH. Data analysis was performed using GEO2R. After identifying the genes and examining the different genes expressed, two gene groups with increased and decreased expression were identified. The interaction of each of the gene groups was examined using the STRING database, based on the co-expression information. The meaningful sub networks were explored using the Clusterone software. Gene ontology was performed using the comparative GO database. The miRNA-mRNA interaction network was also studied based on the miRWalk database. Finally, meaningful networks and subnets obtained by the Cytoscape software, were designed. Results: Comparison of oocyte gene expression data between the pre-maturation and postmaturation stages after treatment with FSH revealed 5958 genes with increased expression and 4275 genes with decreased expression. Examination of the protein interaction network among the set of increased and decreased expression genes based on string information revealed 262 genes with increased expression and 147 genes with decreased expression (high confidence (0.7) data). RPS3, NUSAP1, TBL3, and ATP5H showed increased expression and were effective in the positive regulation of rRNA processing, cell division, mitochondrial ATP synthesis coupled proton, and in oxidative phosphorylation and progesterone-mediated functions. WDR46 and MRPL22 showed decreased expression, which were important in the regulation of SRP-dependent co-translational proteins targeting the membrane, RNA secondary structure, unwinding, and functional pathways of ribosomal and RNA polymerase. The most important miRNA genes in the protein network of increased and decreased gene expression were bta-miR-10b-5p and miR-29b-2-5p. Conclusion: Examination of the genes expressed in the oocyte maturation pathway revealed nuclear, mitochondrial, and miRNA genes. Increasing and decreasing gene expression helps maintain equilibrium, which can be a biological marker.
Numerous works have been written in different languages about the nature of the soul and soul-body relations in the viewpoint of Aristotle. In the meantime, due to the high influence that Ibn Sina has received from Aristotle in his philosophy, a considerable number of these works have also been done as comparative studies on the psychology of Aristotle and Ibn Sina. These works have explained the commonalities of the two philosophers as well as the differences that exist in Ibn Sina's psychology in definition of the soul, its essence, soul-body relations and so on. But no study has independently examined the difference between the soul and life in the viewpoint of Ibn Sina and nor compared these differences with what Aristotle expresses in his works. Our aim in this article is to compare the opinion of Aristotle and Ibn Sina about the nature of the soul and life, and to show how they think differently.
Throughout their lives, people face many events – large and small, pleasant and unpleasant – such as illness, marriage, divorce, the birth of a child, or loss of a job. These can also include the traumatic experience of the death of a family member or a loved one. Relatives and friends have a vital role to play in mourning through understanding the situation of survivors, helping them cope with trauma, relieving their sorrow, and returning them to God. Muslims, especially Iranians, have specific mourning rituals, under the influence of Islam, to console survivors in times of disappointment and loneliness. Most of these common traditional rituals are performed in groups. In the Qur'an and the narrations, many chapters refer to death and invite believers to heal the trauma of survivors and help them to trust in God. This article focuses on the Azeri regions of Iran to introduce the traditional practices of Iranian Muslims and explain how they help support and heal survivors and mourners after the death of a loved one.
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