Background: The purpose of the study is to evaluate and compare the changes associated with hepatosteatosis in diabetic obese versus diabetic normal-weight patients through ultrasonography. It is estimated that with the prevalence of about 30%–75% of obese individuals accordingto the body mass index (BMI) criteria are at increase risk of developing simple fatty live. Besides obesity, diabetes mellitus is also considered to be one of the important causes of hepatosteatosis. Methods: This prospective study was conducted in February 2015–December 2015 on a group of 181 diabetic patients, including 65 males and 116 females with an age range of 40–80 years. The patients were divided into two diabetic groups: those having a BMI ≥30 kg/m 2 were included in the obese group ( n = 116) and those with a BMI of 18.5–25 kg/m 2 were included in the normal BMI group ( n = 65). Ultrasound machine Esaote MyLab 50 equipped with a 3.5–5 MHz curvilinear multifrequency transducer was used to scan the liver. Independent samples t -test was performed to compare the liver span in the two groups. Chi-square tests were applied to compare the frequencies of fatty changes, border, and surface characteristics. Results: The presence of fatty changes among obese groups was statistically significant in the diabetic obese group compared to the normal-weight individuals with P < 0.0001. Similarly, hepatic spans were found to be significantly greater in the diabetic obese group than the diabetic normal BMI group on independent samples t -test with P < 0.0001. Females were seen to develop hepatosteatosis more frequently compared to males in all diabetic individuals with P = 0.02. Conclusion: It is concluded that diabetic obese patients are more prone to develop hepatosteatosis as compared to normal BMI diabetic individuals.

Aim: In this study, we sought to examine the optimal cutoff values for predicting different stages of liver fibrosis, and to determine the level of agreement between shear wave elastography and aspartate aminotransferase to platelet ratio index (APRI) and fibrosis-4 index (FIB-4) scores in patients with chronic liver disease. Methodology: A descriptive, cross-sectional study was performed at the Radiology Department of Shaukat Khanum Memorial Hospital Lahore from 1 Jun 2019 until 1 June 2020. FIB-4 and APRI scores were determined by the following formula: FIB-4 = (age × AST) ÷ (platelet count × (√ (ALT)) and APRI = (AST÷AST upper limit of normal) ÷ platelet × 100. Data was analyzed with the help of SPSS version 24.0 and Microsoft Excel 2013. Results: Eighty individuals were conveniently selected, of which 62.5% were men and 37.5% were women. The mean age of the subjects was 43.47 SD ± 13.85 years. APRI and FIB-4 scores predicted F4 patients using the cutoff values of 0.47 (Sn. 72%, Sp. 70%) and 1.27 (Sn. 78%, Sp. 73%), respectively. The cutoff values of 0.46 for APRI and 1.27 for FIB-4 predicted F3–F4 patients (Sn. 74% and 77%; Sp. 76% and 76%), respectively. To predict F1–F4 compared to F0, the cutoff value was 0.34 (Sn. 68%, Sp. 75%) for APRI, while the cutoff value for FIB was 0.87 (Sn. 72%, Sp. 75%). The findings suggest that FIB-4 shows better diagnostic accuracy than APRI. Conclusion: This study provides optimal cutoff values for different groups of fibrosis patients for both serum markers. Also, the diagnostic accuracy of FIB-4 for predicting liver fibrosis was found to be superior to APRI in all disease stages.

Background: The Presence of palpable breast mass may be an indication of breast cancer. Early and accurate diagnosis for the breast masses is important for therapeutic purpose. Purpose: To assess the diagnostic accuracy of mammographic and sonographic findings in the differentiation of palpable breast masses taking histopathology as a gold standard. Materials and Methods: 134 females were involved in the study. Sonographic and mammographic findings of palpable breast masses were obtained with the help of which diagnostic accuracy of ultrasound and mammography was calculated while taking histopathology as a gold standard. Results: Mean age in 134 females was found to be 44.2±4.7 years. Sn, Sp, PPV, NPV, disease prevalence and accuracy of ultrasound in diagnosis of palpable breast lumps were 99.09%, 79.17%, 95.61%, 95.00%, 82.09% and 95.52% respectively. Sn, Sp, PPV, NPV and accuracy of mammography in diagnosis of palpable breast lumps were 95.45%, 62.50%, 92.11%, 75.00% and 89.55% while disease prevalence was same as that of ultrasound i.e. 82.09% respectively. Conclusion: Ultrasound showed higher diagnostic accuracy in the evaluation of palpable breast masses than mammography while taking histopathology as a gold standard. It is noteworthy in differentiating breast masses.