No abstract

A one-pot, five-component condensation reaction of isocyanide, Meldrum's acid, arylidene malononitrile, and two amine molecules in CH2Cl2 at ambient temperature to give malonamide derivatives is described.

One-Pot Synthesis of 1,2,4,5-Tetrahydro-2,4-dioxobenzo[b][1,4]diazepine and Malonamide Derivatives Using Multi-Component Reactions. -Multicomponent reaction of o-phenylenediamine with arylidene malonitriles, isocyanides, and Meldrum's acid provides diazepines (V) whereas 1,2-diamines with electron-withdrawing substituent as well as p-phenylenediamine give malonamide derivatives. The syntheses can be performed as four-component reactions or as five-component reactions including the in situ formation of arylidene malononitrile substrates. -(RAHMATI*, A.; AHMADI, S.; AHMADI-VARZANEH, M.; Tetrahedron 70 (2014) 50, 9512-9521, http://dx.