One-pot synthesis of 1,2,4,5-tetrahydro-2,4-dioxobenzo[b][1,4]diazepine and malonamide derivatives using multi-component reactions

A Metal-Free Regioselective Multicomponent Approach for the Synthesis of Free Radical Scavenging Pyrimido-Fused Indazoles and Their Fluorescence Studies

“…Multi-component reactions (MCRs) play an important role in combinatorial chemistry [1]. This method has the capability for producing desired small molecule drugs with various degrees of structural diversity [2]. When three or more than three substances or reactants are reacted simultaneously to produce defined target molecules these reactions are said to be MCRs.…”

Metal-bio functionalized bismuthmagnetite [Fe3−xBixO4/SiO2@l-ArgEt3+I−/Zn(ii)]: a novel bionanocomposite for the synthesis of 1,2,4,5-tetrahydro-2,4-dioxobenzo[b][1,4]diazepine malononitriles and malonamides at room temperature and under sonication

“…The known compounds were characterized by comparing the obtained data with their authentic reports. 64 The spectral data of the new derivatives (6e and 6f) are presented in the Experimental section. Furthermore, to extend the efficacy of the novel nano Fe 3Àx Bi x O 4 /SiO 2 @L-ArgEt 3 + I À /Zn(II) the preparation of malonamides 7a-f through a pseudo six-component condensation was performed successfully under the optimal reaction conditions within 10-19 h in 65-98% yield Table 5 (method A).…”

Crystal structure of ethyl (E)-1-(3-ethoxy-3-oxoprop-1-en-1-yl)-2-(4-nitrophenyl)-2,5-dihydro-1H-benzo[b][1,4]diazepine-3-carboxylate, C23H23N3O6

“…Benzo[b] [1,4]diazepines are important nitrogen-containing heterocyclic compounds, which have extensive applications in synthetic chemistry [4][5][6] and medicinal chemistry [7][8][9][10]. The crystal structure of title compound is shown in the figure.…”

“…The bond lengths and angles in the title molecule are in the normal ranges. In conclusion, an efficient and novel one-pot multi-component approach to the synthesis of benzo[b] [1,4]diazepines from simple and readily available starting materials under refluxing conditions without modifications has been developed. We hope that this approach may be of value to others seeking novel synthetic fragments for medicinal chemistry.…”