Objectives Sofosbuvir and daclatasvir are direct-acting antivirals highly effective against hepatitis C virus. There is some in silico and in vitro evidence that suggests these agents may also be effective against SARS-CoV-2. This trial evaluated the effectiveness of sofosbuvir in combination with daclatasvir in treating patients with COVID-19. Methods Patients with a positive nasopharyngeal swab for SARS-CoV-2 on RT–PCR or bilateral multi-lobar ground-glass opacity on their chest CT and signs of severe COVID-19 were included. Subjects were divided into two arms with one arm receiving ribavirin and the other receiving sofosbuvir/daclatasvir. All participants also received the recommended national standard treatment which, at that time, was lopinavir/ritonavir and single-dose hydroxychloroquine. The primary endpoint was time from starting the medication until discharge from hospital with secondary endpoints of duration of ICU stay and mortality. Results Sixty-two subjects met the inclusion criteria, with 35 enrolled in the sofosbuvir/daclatasvir arm and 27 in the ribavirin arm. The median duration of stay was 5 days for the sofosbuvir/daclatasvir group and 9 days for the ribavirin group. The mortality in the sofosbuvir/daclatasvir group was 2/35 (6%) and 9/27 (33%) for the ribavirin group. The relative risk of death for patients treated with sofosbuvir/daclatasvir was 0.17 (95% CI 0.04–0.73, P = 0.02) and the number needed to treat for benefit was 3.6 (95% CI 2.1–12.1, P < 0.01). Conclusions Given these encouraging initial results, and the current lack of treatments proven to decrease mortality in COVID-19, further investigation in larger-scale trials seems warranted.
The present work contains data obtained during the analysis of pregnant women referred to Abadan Health Centers Organization (Abadan HCO) with confirmed acute hypothyroidism diagnosis. From among all pregnant women referred to Abadan HCO, 600 were chosen consisting of 120 pregnant women from each of the health centers in quintuple areas. In this paper, the effects of family history, occupation, death, abortion, type of diabetes, smoking, lithium consumption, allergy, radiotherapy, ovarian cysts (OC) and oral contraceptive pills (OCP) consumption have been studied (Yassaee et al., 2014) [1]. After completion of the questionnaires by the patients, the obtained coded data were fed into ECSELL software. Statistical analysis of the data was carried out using Special Package for Social Sciences version 16 (SPSS 16).
Introduction: Anesthetic gases are very important for health among health care worker (HCWs) and patients in medical centers. Operating rooms (ORs) is the most important ward that use anesthetic gases. Isoflurane gases is very dangerous for HCWs. Objective: In this study, we have associated the concentration of anesthetic toxic isoflurane gases (ppm) and the health risk assessment due to exposure to common anesthetic gases in Valiasr and Shahid Beheshti teaching hospital operating room during 2018. Methods: In this study, we used the active sampling system by portable pump SKC and tubes (sorbent Tube Tenax TA 250 mg) for detection of isoflurane concentration (ppm). Different points of the operating rooms were selected for sampling. Hazard index (HI) quantified by calculating the non-cancer causing anesthetic toxic isoflurane gases. Results: According result this study, the Valiasr and Shahid Beheshti had the lowest and the highest level of isoflurane. Based on result this study, level of isoflurane on indoor air quality in the operation room in Valiasr and Shahid Beheshti hospital were 2.129 and 2.436 ppm, respectively. According to the results from the current study, hazard index was under 1.0 and it amount showed that no significant risk of adverse health endpoint attributed to exposure to level of isoflurane in Valiasr and Shahid Beheshti teaching hospital operating room during 2018. Conclusion: According Result this study the average concentration of isoflurane and the health risk assessment in Valiasr and Shahid Beheshti teaching hospital operating room during 2018 because of flaw in the ventilation system was significantly higher than standard.
The aim of this study was to identify the relationship between the knowledge of leadership and knowledge management practices. This research strategy, in terms of quantity, procedure and obtain information, is descriptive and correlational. Statistical population, consist of all employees of a food industry in Kurdistan province of Iran, who were engaged in 2016 and their total number is about 1800 people. 316 employees in the Kurdistan food industry (Kurdistan FI) were selected, using Cochran formula. Non-random method and valid questions (standard) for measurement of the data are used. Reliability and validity were confirmed. Statistical analysis of the data was carried out, using SPSS 16. The statistical analysis of collected data showed the relationship between knowledge-oriented of leadership and knowledge management activities as mediator variables. The results of the data and test hypotheses suggest that knowledge management activities play an important role in the functioning of product innovation and the results showed that the activities of Knowledge Management (knowledge transfer, storage knowledge, application of knowledge, creation of knowledge) on performance of product innovation.
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