Football is a stop-and-go sport which causes great amount of sweat excretion. Therefore, water and electrolytes replacement is necessary. Sports drinks based on natural compounds, such as coconut water (Cocos nucifera L.), has been highly developed because of its high electrolytes and carbohydrate content. Palmyra saps, as well as coconut water, contains electrolytes and carbohydrate. The ability of palmyra saps water to rehydrate body fluid is still scientifically unproved. This study was conducted using crossover design. Eighteen male students took part in this study. Each subject drank 250 ml of solution before the exercise and 300 ml of solution every 20 minutes during the 2 hours rehydration phase. Blood collections were done 3 times; before exercise, after exercise, and after 2 hours of rehydration. Urine collections were done 3 times; in the morning, after 1 hour of rehydration, and after 2 hours of rehydration. No significant difference (p≥0,05) in palmyra saps brand (ASK) and coconut water brand (AKK) group for blood osmolality and hematocrit. Urinary Na + and K + value after 2 hours rehydration phase in ASK and AKK group have significant difference (p<0.05). Urinary Na + value and urine osmolality after 2 hours rehydration phase in palmyra saps brand and coconut water brand group have significant difference (p<0.05). Significant difference in volume, urine specific gravity and urine color from 2 groups is found between 1 hour after rehydration phase and 2 hours after rehydration phase.
Gastrointestinal symptoms are common health problems found during aging and neurodegenerative diseases. Trimethyltin-induced rat is known as an animal model of hippocampal degeneration with no data on enteric neurodegeneration. This study aimed to investigate the effect of trimethyltin (TMT) induction on the gastrointestinal tract. A 28-day animal study with male Sprague–Dawley rats (3 months old, 150–200 g) given a single TMT injection (8 mg/kg body weight, intraperitoneal) was conducted. The number of neurons in the colonic myenteric plexus was measured using stereological estimation. Histological scoring of colon inflammation, immunohistochemistry of tumor necrosis factor-α (TNF-α), and quantitative PCR were conducted. This study showed neuronal loss in the colonic myenteric plexus of TMT-induced rat model of neurodegeneration. Minor colon inflammation characterized by inflammatory cell infiltration and slightly higher expression of TNF-α in the colon mucosa were observed in the TMT-induced rat. However, the gut microbiota composition of the TMT-induced rat was not different from that of the control rats. This study demonstrates that TMT induces colonic myenteric plexus neurodegeneration and minor colon inflammation, which suggests the potential of this animal model to elucidate the communication between the gastrointestinal tract and central nervous system in neurodegenerative diseases.
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