People sometimes experience an emotional state known as 'nostalgia', which involves experiencing predominantly positive emotions while remembering autobiographical events. Nostalgia is thought to play an important role in psychological resilience. Previous neuroimaging studies have shown involvement of memory and reward systems in such experiences. However, it remains unclear how these two systems are collaboratively involved with nostalgia experiences. Here, we conducted a functional magnetic resonance imaging study of healthy females to investigate the relationship between memoryreward co-activation and nostalgia, using childhood-related visual stimuli. Moreover, we examined the factors constituting nostalgia and their neural correlates. We confirmed the presence of nostalgia-related activity in both memory and reward systems, including the hippocampus (HPC), substantia nigra/ventral tegmental area (SN/VTA), and ventral striatum (VS). We also found significant HPC-VS co-activation, with its strength correlating with individual 'nostalgia tendencies'. Factor analyses showed that two dimensions underlie nostalgia: emotional and personal significance and chronological remoteness, with the former correlating with caudal SN/VTA and left anterior HPC activity, and the latter correlating with rostral SN/VTA activity. These findings demonstrate the cooperative activity of memory and reward systems, where each system has a specific role in the construction of the factors that underlie the experience of nostalgia.
Many mothers are adaptive, deploying successful coping strategies that mitigate the deleterious effects of parenting stress on caregiving, nevertheless, the neural mechanisms underlying these adaptive responses remain unclear. We utilized functional magnetic resonance imaging to investigate brain activity in 28 healthy mothers of typically developing, 2-to-3-year-old children in response to the feeding behavior of their own children versus that of other children. We then examined the correlation between maternal brain activation and subjective feelings of parenting stress. Brain regions associated with maternal motivation including the orbitofrontal cortex (OFC), ventral pallidum, periaqueductal gray (PAG), dorsal raphe nucleus (DRN), and anterior insular cortex (AIC)—as well as those associated with the recognition of one’s own child’s state (e.g., cerebellum)—exhibited significant activation in response to their own children. While mothers with higher activation in the OFC showed less parenting stress related to one’s sense of competence in the parental role, mothers with higher co-activation of the OFC with both of the AIC and PAG/DRN, and with the cerebellum showed less parenting stress caused by child characteristics. Our findings suggest that well-balanced maternal brain mechanisms integrated by the OFC may provide effective adaptive responses in daily parenting scenarios.
The ventrolateral prefrontal cortex (VLPFC) and amygdala have critical roles in the generation and regulation of unpleasant emotions, and in this study the dynamic neural basis of unpleasant emotion processing was elucidated by using paired-samples permutation t-tests to identify the timing of emotional discrimination in various brain regions. We recorded the temporal dynamics of blood-oxygen-level-dependent (BOLD) signals in those brain regions during the viewing of unpleasant pictures by using functional magnetic resonance imaging (fMRI) with high temporal resolution, and we compared the time course of the signal within the volume of interest (VOI) across emotional conditions. Results show that emotional discrimination in the right amygdala precedes that in the left amygdala and that emotional discrimination in both those regions precedes that in the right anterior VLPFC. They support the hypotheses that the right amygdala is part of a rapid emotional stimulus detection system and the left amygdala is specialized for sustained stimulus evaluation and that the right anterior VLPFC is implicated in the integration of viscerosensory information with affective signals between the bilateral anterior VLPFCs and the bilateral amygdalae.
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