Emotional discrimination during viewing unpleasant pictures: timing in human anterior ventrolateral prefrontal cortex and amygdala

Kohno, Satoru; Noriuchi, Madoka; Iguchi, Yoshinobu; Kikuchi, Yoshihiro; Hoshi, Yoko

doi:10.3389/fnhum.2015.00051

Cited by 18 publications

(14 citation statements)

References 57 publications

(58 reference statements)

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“…The evidence that emotion discrimination in the amygdala precedes that in the vlPFC has been also reported in the recent human study (Kohno et al, 2015). The human amygdala has been known to process emotion roughly (Vuilleumier et al, 2003) but rapidly (Balderston et al, 2014).…”

Section: Processing Of Facial Expressions In the Amygdalamentioning

confidence: 80%

Functional differences in face processing between the amygdala and ventrolateral prefrontal cortex in monkeys

Kuraoka¹,

Konoike²,

Nakamura³

2015

Neuroscience

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The ability to categorize social information is essential to survive in a primate's social group. In the monkey brain, there are neural systems to categorize social information. Among these, the relationship between the amygdala and the ventrolateral prefrontal cortex (vlPFC) has recently gained focus with regard to emotion regulation. However, the processing of facial information and the functional differences in these two areas remain unclear. Thus, in this study, we examined the response properties of single neurons in the amygdala and vlPFC while presenting video clips of three types of facial emotions (aggressive threat, coo, and scream) in Macaca mulatta. Neurons in the amygdala were preferentially activated upon presentation of a scream facial expression, which is strongly negative, whereas the neurons in the vlPFC were activated upon presentation of coo, a facial expression with multiple meanings depending on the social context. Information analyses revealed that the amount of information conveyed by the amygdala neurons about the type of emotion transiently increased immediately after stimulus presentation. In contrast, the information conveyed by the vlPFC neurons showed sustained elevation during stimulus presentation. Therefore, our results suggest that the amygdala processes strong emotion roughly but rapidly, whereas the vlPFC spends a great deal of time processing ambiguous facial information in communication, and make an accurate decision from multiple possibilities based on memory.

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Section: Processing Of Facial Expressions In the Amygdalamentioning

confidence: 80%

Functional differences in face processing between the amygdala and ventrolateral prefrontal cortex in monkeys

Kuraoka¹,

Konoike²,

Nakamura³

2015

Neuroscience

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“…Specifically, the left amygdala contributes to dEEM only in women, whereas the bilateral amygdala is associated with the iEEM in both sexes (Cahill et al 2001(Cahill et al , 2004Canli et al 2002;Kilpatrick and Cahill 2003;Mackiewicz et al 2006). Alternatively, the right amygdala was claimed to be part of a rapid emotional stimulus detection system, which would be consistent with a role in affect-based attention, whereas the left amygdala might be specialized for more sustained responses (Phillips et al 2001;Wright et al 2001;Sergerie et al 2008;Kohno et al 2015). In line with a functionaland/or sex-dependent lateralization of amygdala activity, rodents show an anatomical lateralization of the amygdala which is in part sex-dependent (Johnson et al 2008(Johnson et al , 2012Pfau et al 2016).…”

Section: Continuedmentioning

confidence: 99%

Dissociable contributions of the amygdala to the immediate and delayed effects of emotional arousal on memory

Schümann

Sommer

2018

Learn. Mem.

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Emotional arousal enhances memory encoding and consolidation leading to better immediate and delayed memory. Although the central noradrenergic system and the amygdala play critical roles in both effects of emotional arousal, we have recently shown that these effects are at least partly independent of each other, suggesting distinct underlying neural mechanisms. Here we aim to dissociate the neural substrates of both effects in 70 female participants using an emotional memory paradigm to investigate how neural activity, as measured by fMRI, and a polymorphism in the α-noradrenoceptor vary for these effects. To also test whether the immediate and delayed effects of emotional arousal on memory are stable traits, we invited back participants who were a part of a large-scale behavioral memory study ∼3.5 yr ago. We replicated the low correlation of the immediate and delayed emotional enhancement of memory across participants ( = 0.16) and observed, moreover, that only the delayed effect was, to some degree, stable over time ( = 0.23). Bilateral amygdala activity, as well as its coupling with the visual cortex and the fusiform gyrus, was related to the preferential encoding of emotional stimuli, which is consistent with affect-biased attention. Moreover, the adrenoceptor genotype modulated the bilateral amygdala activity associated with this effect. The left amygdala and its coupling with the hippocampus was specifically associated with the more efficient consolidation of emotional stimuli, which is consistent with amygdalar modulation of hippocampal consolidation.

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“…A number of studies have reported that the prefrontal cortex has strong relation to emotional recognition and processing. By recording brain activity with PET and fMRI, it has been shown that the ventrolateral and ventromedial subdivisions of the prefrontal cortex are involved in the integration of emotional processing (Wager et al 2009;Grabenhorst and Rolls 2011;Seo et al 2014;Kohno et al 2015;Silvers et al 2015;Kida and Hoshi 2016;Shiba et al 2016;Machado and Cantilino 2017). The ventrolateral and ventromedial prefrontal subdivisions were activated during viewing unpleasant pictures or processing negative emotion, whereas the cortical regions were deactivated during viewing pleasant pictures or processing positive emotion.…”

Section: Prefrontal Oxygenation During Emotionally Charged Stimulationmentioning

confidence: 99%

Prefrontal oxygenation correlates to the responses in facial skin blood flows during exposure to pleasantly charged movie

Matsukawa

Endo

Asahara

et al. 2017

Physiological Reports

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Our laboratory reported that facial skin blood flow may serve as a sensitive tool to assess an emotional status. Cerebral neural correlates during emotional interventions should be sought in relation to the changes in facial skin blood flow. To test the hypothesis that prefrontal activity has positive relation to the changes in facial skin blood flow during emotionally charged stimulation, we examined the dynamic changes in prefrontal oxygenation (with near‐infrared spectroscopy) and facial skin blood flows (with two‐dimensional laser speckle and Doppler flowmetry) during emotionally charged audiovisual challenges for 2 min (by viewing comedy, landscape, and horror movie) in 14 subjects. Hand skin blood flow and systemic hemodynamics were simultaneously measured. The extents of pleasantness and consciousness for each emotional stimulus were estimated by subjective rating from −5 (the most unpleasant; the most unconscious) to +5 (the most pleasant; the most conscious). Positively charged emotional stimulation (comedy) simultaneously decreased (P < 0.05) prefrontal oxygenation and facial skin blood flow, whereas negatively charged (horror) or neutral (landscape) emotional stimulation did not alter or slightly decreased them. Any of hand skin blood flow and systemic cardiovascular variables did not change significantly during positively charged emotional stimulation. The changes in prefrontal oxygenation had a highly positive correlation with the changes in facial skin blood flow without altering perfusion pressure, and they were inversely correlated with the subjective rating of pleasantness. The reduction in prefrontal oxygenation during positively charged emotional stimulation suggests a decrease in prefrontal neural activity, which may in turn elicit neurally mediated vasoconstriction of facial skin blood vessels.

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Emotional discrimination during viewing unpleasant pictures: timing in human anterior ventrolateral prefrontal cortex and amygdala

Cited by 18 publications

References 57 publications

Functional differences in face processing between the amygdala and ventrolateral prefrontal cortex in monkeys

Functional differences in face processing between the amygdala and ventrolateral prefrontal cortex in monkeys

Dissociable contributions of the amygdala to the immediate and delayed effects of emotional arousal on memory

Prefrontal oxygenation correlates to the responses in facial skin blood flows during exposure to pleasantly charged movie

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