a b s t r a c tBackground: Sesame oil is a potent antioxidant dietary source for human health. Oxidative stress through generation of free radicals damages the myocardium in different experimental condition. The present research was designed to evaluate the antioxidant property of chronic oral administration of sesame oil against isoproterenol induced myocardial injury. Methods and results: Male Wistar albino rats were randomly divided into five groups (n ¼ 6) and treated as per treatment protocol with two different doses of sesame oil (5 and 10 ml/kg b.w.) orally for thirty days. At the end of the treatment all the rats (except control rats) were administered with isoproterenol (85 mg/kg) two consecutive days and subjected to biochemical and histopathological estimation. Isoproterenol (group ISO) induced the oxidative myocardial damage via alteration in the endogenous antioxidant enzymes and myocardial marker enzymes. Sesame oil in both the dose (group S1 and S2) shows protective mechanism via decreasing thiobarbituric acid reactive substance (TBARS) and enhancing the endogenous antioxidant enzymes (reduced glutathione (GSH), superoxide dismutase (SOD) and Catalase). Sesame oil also increased the lactate dehydrogenase (LDH), creatine kinase (CK) and aspartate transaminase (AST) as a myocardial marker enzyme in heart homogenate. As histologically evident isoproterenol induced myocardial injury was well preserved by the chronic administration of sesame oil. The protective role of sesame oil was compared with the reference standard a-tocopherol (group S3) also showing the similar effect. Conclusion: From this finding it has been concluded that chronic administration of sesame oil offers cardio protective action via putative antioxidant property.
T he objective of the present study was to evaluate the compatibility of propafenone HCl (PFH) with the selected excipients used in a controlled drug delivery system. The studies were conducted by an isothermal stress test method. The differential scanning calorimetry (DSC) and high-performance liquid chromatography techniques were used as tools to assess the compatibility of the drug with the selected excipients. Complementary techniques such as powder X-ray powder diffractometry (pXRD) and fourier transform infrared (FTIR) spectroscopy were used to assist in the interpretation of the DSC results. On the basis of the DSC results, the drug was found to be compatible with gum kondagogu (GKG), chitosan, polyelectrolyte complex of GKG and chitosan, HPMC K100M, carbopol 934P, Benecel ® and A-tab ® . Some degree of interaction was observed with lactose monohydrate; however, the additional studies using FTIR spectroscopy and pXRD confirmed that PFH is compatible with lactose monohydrate.
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