No abstract

A sensitive and selective liquid chromatography-tandem mass spectrometry (LC-MS/MS) method was developed and validated for simultaneous determination of urapidil and aripiprazole in human plasma. A simple liquid-liquid extraction with ethyl acetate was used for the sample preparation. Chromatographic separation was achieved on a Phenomenex C18 (4.6 × 50 mm, 5 µm) column with 0.1% formic acid-acetonitrile (10:90, v/v) as the mobile phase with flow rate of 0.6 mL/min. The quantitation of the target compounds was determined in a positive ion multiple reaction monitoring mode. Calibration plots were linear over the range of 2.0-2503.95 ng/mL for urapidil and 1.0-500.19 ng/mL for aripiprazole. The lower limit of quantitation for urapidil and aripiprazole was 2.0 and 1.0 ng/mL, respectively. Mean recovery was in the range of 69.94-75.62% for both analytes and internal standards. Intra-day and inter-day precisions of the assay at three concentrations were 2.56-5.89% with accuracy of 92.31-97.83% for urapidil, and 3.14-6.84% with accuracy of 91.38-94.42% for aripiprazole. The method was successfully applied to human pharmacokinetic study of urapidil and aripiprazole in healthy human male volunteers.

Nanotechnology is gaining tremendous impulsion in the present century due to its capability of modulating metals into their nanosize. They exhibit a high surface/volume ratio leading to different properties far different from those of the bulk materials. The development of uniform nanoparticles has been intensively pursued because of their technological and fundamental scienti?c importance. The use of iron-based technologies is a rapidly developing field, with a range of techniques proposed which make use of iron as a reductant, or as a sorbent, which have been tested at various scales of application. In this study the iron based materials were synthesized by precipitation method and characterized with SEM equipped with EDS, UV-VIS, FT-IR, Raman, particle size determination and Zeta potential.

Chromium is an important industrial metal used in various products and processes but at the same time causing lethal environmental hazards. Remediation of Cr-contaminated soils poses both technological and economic challenges, as conventional methods are often too expensive and difficult to operate. Zero-valent iron particles at nanoscale are proposed to be one of the important reductants of Cr(VI), transforming the same into nontoxic Cr(III). In the present investigation, soils contaminated with Cr(VI) are allowed to react with the various loadings of zero-valent iron nanoparticles (Fe 0 ) for a reaction period of 24 h. Fe 0 nanoparticles were synthesized by the reduction of ferrous sulfate in the presence of sodium borohydride and stabilized with carboxy methyl cellulose and were characterized by scanning electron microscopy, energy dispersion spectroscopy, X-ray diffraction, UV-vis spectrophotometer, Fourier transform-infra red spectrophotometer, Raman spectroscopy, dynamic light scattering technique and zeta potential. Further, this work demonstrates the potential utilization of farm yard manure (FYM) and Fe 0 nanoparticles in combination and individually for the effective remediation of Cr(VI)-contaminated soils. An increase in the reduction of Cr(VI) from 60 to 80 % was recorded with the increase in the loading of Fe 0 nanoparticles from 0.1 to 0.3 mg/100 g individually and in combination with FYM ranging from 50 to 100 mg/100 g soil.

No abstract

No abstract

No abstract

No abstract