Synthesis of six-membered bicyclic, tricyclic or tetracyclic Nheterocycles are important due to enormous use of such scaffolds in bioactive natural products, agrochemicals and in pharmaceuticals. [3 + 3] cycloaddition of azomethine imine for the construction of such heterocycles is less explored but also a genuine approach with the other method like [4 + 2] and [2 + 2 + 2] cycloaddition. Hence, the literature survey in this area is utmost significant. The delights and difficulties of [3 + 3] cycloaddition of azomethine imine have been deliberated thoroughly to elucidate this highly mounting field in this literature study. Herein, we report a vast synthetic method [base catalyzed, metal catalyzed (racemic and asymmetric), phosphine catalyzed, NHC and Lewis acid catalyzed] for the synthesis of di, tri and tetra-nitrogen containing heterocycles via [3 + 3] cycloadditon reaction of azomethine imine.
Herein we report an organocatalytic synthesis of highly fluorescent naphthalene derivatives through hydrogen atom transfer featuring neat and mild reaction conditions under air with high substrate tolerance along with atom economy by the unprecedented use of DBU, where oxidation and reduction occurred in one‐pot. Synthesized compounds are utilized in photophysical studies, cytotoxic studies and cell imaging studies of colon cancer cell line CT26.
Di, tri and tetra‐nitrogen containing 7‐membered heterocycles are the key building blocks for natural and medicinally active compounds. They are using as antidepressants, antiulcer, antibiotics, antiemetic and also used as herbicides and insecticides. These building blocks can be synthesized easily from [4 + 3] cycloadditon reaction of azomethine imine with the other suitable reacting partner. Research on this area is very much important as this area is not much explored till now. Hence, the synthetic literature survey towards the di‐nitrogen containing heterocycles is paramount importance. Herein, we report numerous synthetic routes (metal catalyzed, metal free, asymmetric) of di‐nitrogen containing 7‐membered heterocycle through [4 + 3] cycloadditon reaction of the last 10 years (2011‐2019).
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