Synthesis of six-membered bicyclic, tricyclic or tetracyclic Nheterocycles are important due to enormous use of such scaffolds in bioactive natural products, agrochemicals and in pharmaceuticals. [3 + 3] cycloaddition of azomethine imine for the construction of such heterocycles is less explored but also a genuine approach with the other method like [4 + 2] and [2 + 2 + 2] cycloaddition. Hence, the literature survey in this area is utmost significant. The delights and difficulties of [3 + 3] cycloaddition of azomethine imine have been deliberated thoroughly to elucidate this highly mounting field in this literature study. Herein, we report a vast synthetic method [base catalyzed, metal catalyzed (racemic and asymmetric), phosphine catalyzed, NHC and Lewis acid catalyzed] for the synthesis of di, tri and tetra-nitrogen containing heterocycles via [3 + 3] cycloadditon reaction of azomethine imine.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.