ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract, please click on HTML or PDF.
In the context of aminoglycosides as efficient binders to RNA, a 2,6-diaminogalactose scaffold was developed for combinatorial syntheses of potential RNA ligands in the solid phase. A set of selectively removable, orthogonally stable protecting groups in combination with a linker stable throughout the synthesis, but selectively cleavable in the detachment process, allows for selective deprotection and introduction of a side chain in each position of this scaffold. A few of the synthesized compounds exhibit inhibition of HIV-1 infection in HeLa cells that contain a TAR-controlled reporter gene.
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